Protumor effects of proinflammatory mediators in breast cancer

Inflammation is defined as an enabling characteristic of malignant growth. Many proinflammatory mediators have protumor capabilities. In this review we focus on the protumor effect of cytokines and chemokines in breast cancer. We discuss the role of interleukin 1β, interleukin 6, tumor necrosis factor α, CCL2, CCL5, and CXCL12 and its receptor CXCR4 as typical mediators implicated in breast cancer progression. We also analyze the impact of transcription factor NF-κB. Proinflammatory mediatorswith protumor effects should be considered as therapeutic targets in breast cancer. It is challenging how to find optimal anti-cytokine and anti-chemokine regiments as a part of anticancer therapy