Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles

The present work deals with the synthesis of some novel heterocyclic compounds such as benzoxazoles 2, 7, 13 and 19, imidazoles 3, 8, 14 and 20, benzimidazole 4, 9, 15 and 21, tetrazoles 10, 16, and 22. The synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The compounds were evaluated for cytotoxicity against human cancer cell line such as, MCF-7 (breast cancer) and HT-29 (colon cancer) by MTT assay method. Among the tested compounds, compounds 4,4’-sulfonylbis(N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)aniline (9), N-bis(2-(benzo[d]oxazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (13), N-bis(2-(1H-benzo[d]imidazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (15) and N-tris(2-1H-benzo[d]imidazol-2-yl)ethyl)-1,3,5-triazine-2,4,6-triamine (21) show potent cytotoxicity