Fixed combination of felodipine and metoprolol in treatment of hypertension.

The therapy with combination of felodipine and metoprolol in treatment of hypertension results in satisfactory effect with hypertensive patients on lowering the values of systolic and diastolic blood pressure (BP). This effect is sustained during the period over two years, while lowering of systolic and diastolic BP results in reduction of total cardiovascular complications: reduction of incidence of stroke for one third of patients and myocardial infarction for one sixth of patients. This fixed combination is applicable with patients that did not manage to regulate BP by using some other specific antihypertensive drugs, achieving sustained lowering of BP in a 24-hour period. There are fewer side-effects associated with this therapy than with the fixed combinations of antihypertensive drugs used so far, since there are no negative metabolic effects and therefore it may be applied in high risk patients with metabolic syndrome and diabetes. The application of the fixed combination of felodipine and metoprolol may achieve the set targets related with lowering of BP and reducing cardiovascular risk efficiently in 70-89% patients. Both felodipine and metoprolol are individually applied in treatment of coronary heart disease whereas this combination may lead to coronary protection