Specifičnosti hematoloških laboratorijskih nalaza kod velikih zahvata tumora glave i vrata

The aim of the study was to determine the incidence of coagulation disorders and possible differences between patients operated on for head and neck tumors with and without blood transfusion treatment. The study included 31 patients divided into two groups: 16 patients with and 15 patients without intraoperative administration of blood transfusion. The following laboratory parameters were monitored: leukocyte count, erythrocyte count, hemoglobin, hematocrit, platelet count, activated partial thromboplastin time, prothrombin time, fibrinogen, thrombin time, and fibrinolysis. Data were statistically analyzed by Student’s t-test for dependent and independent samples, and by simple correlation. The results showed prothrombin time to be statistically significantly reduced postoperatively in both patient groups, while fibrinolysis was statistically significantly accelerated in the group of patients who received intraoperative blood transfusion. Accordingly, in patients administered blood transfusion during the surgery, fibrinolysis was statistically significantly accelerated in comparison with their preoperative values. In the group of patients who did not receive intraoperative blood transfusion, fibrinolysis remained within the physiological range.Cilj ispitivanja bio je utvrditi učestalost poremećaja zgrušavanja krvi u bolesnika operiranih zbog tumorskog procesa glave i vrata, te moguću razliku između bolesnika koji su tijekom operacije primali transfuziju i onih koji to nisu. Ukupno je 31 bolesnik bio obuhvaćen ispitivanjem. Bolesnici su bili podijeljeni u dvije skupine: 16 bolesnika je primalo transfuziju tijekom operacijskog zahvata, a 15 bolesnika nije primalo transfuziju. Praćeni su sljedeći laboratorijski parametri: broj leukocita, broj eritrocita, hemoglobin, hematokrit, broj trombocita, aktivirano parcijalno tromboplastinsko vrijeme, protrombinsko vrijeme, fibrinogen, trombinsko vrijeme i fibrinoliza. Podaci su bili statistički obrađeni Studentovim t-testom za zavisne i nezavisne uzorke, te jednostavnom korelacijom. Rezultati su pokazali statistički značajno skraćenje protrombinskog vremena nakon operacije u objema skupinama, dok je fibrinoliza bila statistički značajno ubrzana u skupini bolesnika koji su primali transfuziju. Dakle, u skupini bolesnika koji su primali transfuziju zabilježeno je statistički značajno ubrzanje fibrinolize nakon operacije u usporedbi s prijeoperacijskim vrijednostima. U bolesnika koji nisu primali transfuziju fibrinoliza je ostala u fiziološkim granicama