Despite the importance of mitochondrial fatty acid oxidation (FAO) in cancer metabolism, the biological mechanisms responsible for the FAO in cancer and therapeutic intervention based on catabolic metabolism are not well defined. In this study, we observe that Snail (SNAI1), a key transcriptional repressor of epithelial-mesenchymal transition, enhances catabolic FAO, allowing pro-survival of breast cancer cells in a starved environment. Mechanistically, Snail suppresses mitochondrial ACC2 (ACACB) by binding to a series of E-boxes located in its proximal promoter, resulting in decreased malonyl-CoA level. Malonyl-CoA being a well-known endogenous inhibitor of fatty acid transporter carnitine palmitoyltransferase 1 (CPT1), the suppression of ...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance m...
A considerable amount of data have accumulated in the last decade on the pronounced mitochondrial fa...
Cancer cells can be killed by reducing the production of ATP from various pathways, however, this ha...
Efficient catabolic metabolism of adenosine triphosphate (ATP) and reduced nicotinamide adenine dinu...
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP...
SummaryThe epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor ce...
During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a r...
The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells wit...
Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have been sho...
Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have been sho...
SummaryTransmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondria...
Abstract Background Altered cellular metabolism is a hallmark of cancer but the association between ...
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial repro...
Background Deregulation of the tricarboxylic acid cycle (TCA) due to mutations in specific enzyme...
BACKGROUND: Necrosis, a type of cell death accompanied by the rupture of the plasma membrane, promot...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance m...
A considerable amount of data have accumulated in the last decade on the pronounced mitochondrial fa...
Cancer cells can be killed by reducing the production of ATP from various pathways, however, this ha...
Efficient catabolic metabolism of adenosine triphosphate (ATP) and reduced nicotinamide adenine dinu...
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP...
SummaryThe epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor ce...
During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a r...
The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers tumor cells wit...
Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have been sho...
Both cytosolic fatty acid synthesis (FAS) and mitochondrial fatty acid oxidation (FAO) have been sho...
SummaryTransmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondria...
Abstract Background Altered cellular metabolism is a hallmark of cancer but the association between ...
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial repro...
Background Deregulation of the tricarboxylic acid cycle (TCA) due to mutations in specific enzyme...
BACKGROUND: Necrosis, a type of cell death accompanied by the rupture of the plasma membrane, promot...
Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance m...
A considerable amount of data have accumulated in the last decade on the pronounced mitochondrial fa...
Cancer cells can be killed by reducing the production of ATP from various pathways, however, this ha...