Interleukin-1 beta, -6 and interferon-gamma productions in patients undergoing continuous ambulatory peritoneal dialysis

In order to investigate cytokine productions in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), we studied the production of interleukin (IL)-1 β, -6 and interferon (IFN)-γ by cultured peripheral blood mononuclear cells (PBMC) in peritonitis-free CAPD patients. The correlation of cytokine production with plasma parathyroid hormone (PTH) and albumin levels was also evaluated. While the release of IL-1 β was not markedly different from controls release of IL-6 from 24-hour cultured PBMCs was significantly greater than that of controls, (Mean ± S.D., IL-6: 2186.8 ± 1217.9 pg/ml, vs 1516.3 ± 767.9, P 0.05). No difference of baseline IFN-γ was detected between CAPD patients controls, but phytohemagglutinin (PHA, 10 µg/ml)-stimulated IFN-γ release was significantly higher in CAPD patients than controls (2425.9 ± 1565.0 pg/ml vs 1364.0 ± 755.1, P <0.05). There was no significant correlation between PTH and, IL-1 β, serum albumin level and LPS-stimulated IL-6 production (r = 0.54, P