Prevalence of persistent symptoms after treatment for lyme borreliosis: A prospective observational cohort study.
- Ursinus, Jeanine
- Vrijmoeth, Hedwig D
- Harms, Margriet G
- Tulen, Anna D
- Knoop, Hans
- Gauw, Stefanie A
- Zomer, Tizza P
- Wong, Albert
- Friesema, Ingrid H M
- Vermeeren, Yolande M
- Joosten, Leo A B
- Hovius, Joppe W
- Kullberg, Bart Jan
- van den Wijngaard, Cees C
DOIAbstract
Of 1135 LB patients (94•8% erythema migrans, 5•2% disseminated LB), 1084 fulfilled primary analysis criteria, as well as 1942 population and 1887 tick-bite controls. Overall prevalence of persistent symptoms in LB patients was 27•2% (95%CI, 24•7%-29•7%); 6•0% and 3•9% higher than in population (21•2%, 95%CI, 19•3%-23•1%; p < 0•0001) and tick-bite (23•3%, 95%CI 21•3%-25•3%; p = 0•016) cohorts, respectively. At 12 months, fatigue, cognitive impairment, and pain were significantly more severe in erythema migrans patients than in reference cohorts, while in disseminated LB patients, only pain was more severe
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