Add to ORKGTreball de fi de grau en Bioinformàtica. Curs 2020-2021Tutor: Trisevgeni RapakouliaWe applied an enhancer prediction method to an extensive set of epigenetic profiles from the ENCODE project. We identified enhancer elements in 104 human primary cells, cell lines, and tissues. This extensive generation of enhancer profiles allowed us to identify groups of cell types that are pretty similar in terms of enhancer usage and cell types that differ significantly. A case study on adult brain and embryo placenta tissues with quite different sets of active enhancers revealed cell-type specific enhancers that regulate the expression of genes linked to the tissue phenotype. Further exploitation of additional cell groups can reveal the lineage-specific ...
With the recent identification of over 100 histone modifications in mammalian cell-types, there is a...
The collection of RNA sequencing experiments produced by the ENCODE project from many cell lines and...
Background. Transcriptional enhancers are generally known to regulate gene transcription from afar. ...
Experimentally characterized enhancer regions have previously been shown to display specific pattern...
Experimentally characterized enhancer regions have previously been shown to display specific pattern...
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multi...
Epigenetic modifications, transcription factor (TF) availability and chromatin conformation influenc...
Enhancers are important noncoding elements, but they have been traditionally hard to characterize ex...
Transcriptional enhancers play critical roles in regulation of gene expression, but their identifica...
There are over 200 cell types in the human body, each with a unique gene expression program precisel...
Gene-regulatory enhancers have been identified using various approaches, including evolutionary cons...
Epigenetic regulation is dynamic and cell-type de-pendent. The recently available epigenomic data in...
Enhancers are important non-coding elements, but they have traditionally been hard to characterize e...
<div><p>Transcriptional enhancers play critical roles in regulation of gene expression, but their id...
With the recent identification of over 100 histone modifications in mammalian cell-types, there is a...
The collection of RNA sequencing experiments produced by the ENCODE project from many cell lines and...
Background. Transcriptional enhancers are generally known to regulate gene transcription from afar. ...
Experimentally characterized enhancer regions have previously been shown to display specific pattern...
Experimentally characterized enhancer regions have previously been shown to display specific pattern...
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multi...
Epigenetic modifications, transcription factor (TF) availability and chromatin conformation influenc...
Enhancers are important noncoding elements, but they have been traditionally hard to characterize ex...
Transcriptional enhancers play critical roles in regulation of gene expression, but their identifica...
There are over 200 cell types in the human body, each with a unique gene expression program precisel...
Gene-regulatory enhancers have been identified using various approaches, including evolutionary cons...
Epigenetic regulation is dynamic and cell-type de-pendent. The recently available epigenomic data in...
Enhancers are important non-coding elements, but they have traditionally been hard to characterize e...
<div><p>Transcriptional enhancers play critical roles in regulation of gene expression, but their id...
With the recent identification of over 100 histone modifications in mammalian cell-types, there is a...
The collection of RNA sequencing experiments produced by the ENCODE project from many cell lines and...
Background. Transcriptional enhancers are generally known to regulate gene transcription from afar. ...