CONTEMPORARY TREATMENT OF HER2 POSITIVE EARLY BREAST CANCER

Karcinom dojke danas je najčešća maligna bolest u ženskoj populaciji i još uvijek najčešći uzrok smrti od malignih bolesti u žena. No svakodnevno se događa napredak u liječenju tog javnozdravstvenog problema. Metastatsko sijelo koje se javlja tijekom napredovanja bolesti kod bolesnica s ranim rakom dojke od iznimne je važnosti pri određivanju ishoda bolesti. Primarna prevencija raka dojke na populacijskoj razini se odnosi na modifikaciju promjenjivih čimbenika rizika, koji uključuju promjenu životnog stila, povećanje tjelesne aktivnosti. Sekundarna prevencija kao glavni izbor definira mamografiju, odnosno rano otkrivanje raka dojke. Zadnjih godina podaci sve više ističu ulogu ranog otkrivanja i dijagnosticiranja karcinoma dojke, te iako se mamografski pregled smatra i dalje najbitnijom metodom dijagnosticiranja, sve je više i ostalih dijagnostika koje pridonose upravo toj važnosti. Karcinom dojke je heterogena bolest, te se odluka o liječenju donosi na temelju karakteristika tumora, stadiju u kojem je otkrivena bolest, obilježjima bolesnice i u skladu s njezinim željama. Adjuvantno liječenje ranog karcinoma dojke može uključivati kemoterapiju, hormonsku terapiju i anti-HER2 terapiju, te radioterapiju.Breast cancer is today the most common malignancy in the female population and still the most common cause of death from malignant diseases in women. But progress is being made every day in treating this public health problem. The metastatic site that occurs during disease progression in patients with early breast cancer is extremely important in determining disease outcome. Primary prevention of breast cancer at the population level refers to the modification of variable risk factors, which include lifestyle changes, increased physical activity. Secondary prevention defines mammography as the main choice, ie early detection of breast cancer. In recent years, data have increasingly highlighted the role of early detection and diagnosis of breast cancer, and although mammography is still considered the most important method of diagnosis, there are more and more other diagnoses that contribute to this importance. Breast cancer is a heterogeneous disease, and the decision on treatment is made based on the characteristics of the tumor, the stage at which the disease is detected, the characteristics of the patient and in accordance with her wishes. Adjuvant treatment of early breast cancer may include chemotherapy, hormone therapy and anti-HER2 therapy, and radiotherapy