Evaluation of Antinociceptive Effect of Mallotus Philippensis Extract against STZ Induced Diabetic Neuropathy in Wistar Albino Rats

The present study was to investigate the Neuroprotective effect of EEMP in experimentally induced diabetic neuropathy in rats. Diabetogenic effect of STZ is more reproducible and the metabolic changes are much closer to those existing in human diabetes. Hence STZ is considered the drug of choice for the induction of experimental diabetes. The Blood glucose level and HbA1significantly decreased with treatment of EEOA proves that it has anti-diabetic activity. The study shows marked inhibit in oxidative stress by enhancing reduced activity of antioxidant enzyme SOD, CAT, GSH & Markedly elevate the level of LPO in liver compare to control animals, these findings further strengthen beneficial effect of Mallotus philippensis as it showed production against STZ induced diabetic neuropathic pain in rats. After 4th week, control has shown signs of neuropathy while treated group has showed significant improvement in their condition. From this results, it is evident that EEMP has beneficial effect in protective against STZ- induced diabetic neuropathy in rats. Histopathological assessment also showed that the damage caused by STZ to the sciatic nerve is also markedly reduced by the administration of Mallotus philippensis. Finally, these findings suggest that Mallotus philippensis treatment must be beneficial to treat pain in diabetic animals