For the next generations of wireless communication systems, getting higher spectral efficiencies is remaining a big challenge to answer the explosively increasing demand of throughput. Meanwhile, the energy consumption of equipments and the transmitting power density have to be reduced to achieve the objective of ‘’green communications’’. One of the most promising strategies to deal with such issues is using multi-user multiple-input multiple-output (MU-MIMO) schemes, namely for large-scale antenna systems. It becomes then possible to simultaneously serve multiple simple device users using linear spatial precoding techniques. The objective of this thesis is to optimize the spectral efficiency of MU-MIMO systems in the context of moderate-sc...