0418: Comparison of pre- and post-operative characteristics in octogenarians having isolated surgical aortic valve replacement before versus after introduction of transcatheter aortic valve implantation

International audience0418 – Figure Surgical aortic valve replacement (SAVR) is the reference treatment for severe aortic stenosis (AS). Transcatheter aortic valve implantation (TAVI) has emerged as an alternative treatment. The aim of the study was to assess if the clinical profile of octogenarian patients treated surgically before and after the TAVI program initiation has changed. We retrospectively included consecutive octogenarian patients, who underwent isolated SAVR, between January 2006 and December 2014 in a single high-volume center. We compared preoperative, peri-operative and postoperative characteristics before and after the initiation of TAVI (February 2009). 845 patients were included: 229 in the pre-TAVI group (2006-2008; 3 years), 616 in the post-TAVI group (2009-2014; 6 years). Over time, there was an increased rate of SAVR performed. The mean age was the same, 83.2±2.0 years in the pre-TAVI group, 83.5±2.1 years in the post-TAVI group (p=0.06). The preoperative characteristics were statistically comparable, except for history of heart failure (25% in the pre-TAVI group vs 18% in the post-TAVI group, p=0.04), coronary artery disease (22% in the pre-TAVI group vs 14% in the post-TAVI group, p=0.01), hypertension (59% in the pre-TAVI group vs 68% in the post-TAVI group, p=0.02) and obesity (18% in the pre-TAVI group vs 24% in the post-TAVI group, p=0.03). Peri-operative data and post-operative adverse events were comparable between both groups. The operative mortality (30-day) was similar, 5.2% in the pre-TAVI group, 5.5% in the post-TAVI group (p=0.87). In conclusion, with the emergence of TAVI, the number of octogenarian patients operated on continued to increase, their preoperative characteristics were clinically similar and the operative mortality was stabl