Synthesis and application of 2-naphthol derivative

Alzheimerjeva bolezen je ena izmed najbolj raziskovanih nevrodegenerativnih bolezni. Gre za progresivno nevrološko motnjo, ki zmanjša velikost možganov in vodi k odmrtju možganskih celic. Fluorescenčne sonde se pogosto uporabljajo v kliničnih raziskavah in diagnozi Alzheimerjeve bolezni. V tem delu je predstavljena sinteza dveh derivatov naftola, katerih optične lastnosti bi lahko s pridom uporabljali na različnih področjih znanosti. Gre za 6-acetil-2-(dimetilamino)naftalen in 1-{6-[(2-hidroksietil)(metil)amino]-2-naftil}etanon, oba sintetizirana iz 1-(6-hidroksinaftalen-2-il)etanona.Alzheimer disease is one of the most researched neurodegenerative diseases. It is a progressive neurological disorder that reduces the size of the brain and leads to the death of brain cells. Fluorescent probes are widely used in clinical trials and the diagnosis of Alzheimer disease. This thesis presents the synthesis of two naphthol derivatives, optical properties of which could be used to advantage in various fields of science. These are 6-acetyl-2-(dimethylamino)naphthalene and 1-{6-[(2-hydroxyethyl)(methyl)amino]-2-naphthyl}ethanone, both synthesized from 1-(6-hydroxynaphthalen-2-yl)ethanone