This chapter discusses practice-led and interdisciplinary methods in sound design research. Sound design can be undertaken as a creative activity in combination with theoretical investigation, so that theory informs practice, while conversely, the generation of new practical approaches provides new theoretical insights. The authors discuss how this may provide a suitable methodology for research in sound design, where sound artifacts themselves may transmit and advance knowledge in the field, but may also be complemented and disseminated through means of papers and publications. Furthermore, the authors also argue that practice-led methods can be used in combination with other empirical approaches, which may help to reinforce the outcomes. ...