Evaluating Inflammatory Versus Mechanical Back Pain in Individuals with Psoriatic Arthritis: A Review of the Literature

Plain Language Summary Psoriatic arthritis (PsA) is a long-term disease that may lead to psoriatic changes in skin and nails; inflammation of some joints, including finger and toe joints (dactylitis); inflammation of sites where tendons and ligaments connect to bone (enthesitis); and/or problems in the spine (axial involvement). Approximately 25–70% of patients with PsA have axial involvement (axPsA); this number varies because there is no widely accepted definition for axPsA. Chronic (long-lasting) back pain is a major feature of axSpA and can help doctors recognize axPsA early. Chronic back pain can be caused by inflammatory back pain (IBP) or mechanical back pain (MBP). IBP is described by back pain lasting ≥ 3 months, gradual onset at age < 40 years, improvement with exercise, no improvement with rest, pain at night (with improvement upon getting up), and changes in some laboratory test results. On the other hand, MBP is caused by a physical injury to the lower back. Both IBP and MBP can occur in patients with PsA, but they are treated in different ways. Being able to tell the difference between IBP and MBP is important to make sure that patients receive the right treatment. This review looks at the differences between IBP and MBP, screening for IBP, the difficulties and limitations of diagnosing and treating axPsA, and the needs of patients with axPsA for better diagnosis and treatment