PurposeThis study aimed to evaluate the bone turnover markers and bone microarchitecture parameters derived from high-resolution peripheral quantitative computed tomography (HR-pQCT) in active and controlled acromegaly patients.MethodsThis cross-sectional study involved 55 acromegaly patients from a tertiary hospital (23 males and 32 females, aged 45.0 ± 11.6 years). Firstly, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and markers for bone turnover were assessed. Next, we derived peripheral bone microstructure parameters and volumetric bone mineral density (vBMD) through HR-pQCT. These parameters were compared between acromegaly patients and 110 healthy controls, as well as between 27 active and 28 controlled acromegaly patie...
Abstract OBJECTIVE: Data on bone mineral density (BMD) in acromegaly are conflicting as most previ...
Hypersecretion of growth hormone (GH) is rare and typically results from a pituitary functional tumo...
Copyright © 2012 Zdenko Killinger et al. This is an open access article distributed under the Creati...
Context: Acromegalic patients have an increased vertebral fracture (VFx) risk due to bone quality re...
Objective : Data on trabecular bone mass in acromegaly are controversial. All the studies are cross-...
Long‐standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typic...
CONTEXT: The high risk of vertebral fractures (VFs) in acromegaly patients despite normal bone mine...
OBJECTIVE: Acromegaly is a rare disease caused by excess growth hormone (GH) production by the pitui...
Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficu...
Acromegaly may induce abnormalities in bone metabolism; however, there are limited data related to b...
Background: a high prevalence of vertebral fractures, despite normal bone mineral density (BMD), is ...
Growth Hormone (GH) and Insulin-like Growth Factor (IGF-1) stimulate proliferation, differentiation ...
OBJECTIVE: Data on bone mineral density (BMD) in acromegaly are conflicting as most previous studies...
Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growt...
Growth hormone (GH) deficiency and acromegaly serve as good models for investigating the effects of ...
Abstract OBJECTIVE: Data on bone mineral density (BMD) in acromegaly are conflicting as most previ...
Hypersecretion of growth hormone (GH) is rare and typically results from a pituitary functional tumo...
Copyright © 2012 Zdenko Killinger et al. This is an open access article distributed under the Creati...
Context: Acromegalic patients have an increased vertebral fracture (VFx) risk due to bone quality re...
Objective : Data on trabecular bone mass in acromegaly are controversial. All the studies are cross-...
Long‐standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typic...
CONTEXT: The high risk of vertebral fractures (VFs) in acromegaly patients despite normal bone mine...
OBJECTIVE: Acromegaly is a rare disease caused by excess growth hormone (GH) production by the pitui...
Vertebral fractures are an emerging complication of acromegaly but their prediction is still difficu...
Acromegaly may induce abnormalities in bone metabolism; however, there are limited data related to b...
Background: a high prevalence of vertebral fractures, despite normal bone mineral density (BMD), is ...
Growth Hormone (GH) and Insulin-like Growth Factor (IGF-1) stimulate proliferation, differentiation ...
OBJECTIVE: Data on bone mineral density (BMD) in acromegaly are conflicting as most previous studies...
Acromegaly is caused by hypersecretion of growth hormone (GH) and consequently of insulin-like growt...
Growth hormone (GH) deficiency and acromegaly serve as good models for investigating the effects of ...
Abstract OBJECTIVE: Data on bone mineral density (BMD) in acromegaly are conflicting as most previ...
Hypersecretion of growth hormone (GH) is rare and typically results from a pituitary functional tumo...
Copyright © 2012 Zdenko Killinger et al. This is an open access article distributed under the Creati...