Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
- McCartney, D.L.
- Min, J.L.
- Richmond, R.C.
- Lu, A.T.
- Sobczyk, M.K.
- Davies, G.
- Broer, L.
- Guo, X.
- Jeong, A.
- Jung, J.
- Kasela, S.
- Katrinli, S.
- Kuo, P.L.
- Matias-Garcia, P.R.
- Mishra, P.P.
- Nygaard, M.
- Palviainen, T.
- Patki, A.
- Raffield, L.M.
- Ratliff, S.M.
- Richardson, T.G.
- Robinson, O.
- Soerensen, M.
- Sun, D.
- Tsai, P.C.
- van der Zee, M.D.
- Walker, R.M.
- Wang, X.
- Wang, Y.
- Xia, R.
- Xu, Z.
- Yao, J.
- Zhao, W.
- Correa, A.
- Boerwinkle, E.
- Dugué, P.A.
- Durda, P.
- Elliott, H.R.
- Gieger, C.
- de Geus, E.J.C.
- Harris, S.E.
- Hemani, G.
- Imboden, M.
- Kähönen, M.
- Kardia, S.L.R.
- Kresovich, J.K.
- Li, S.
- Lunetta, K.L.
- Mangino, M.
- Mason, D.
- McIntosh, A.M.
- Mengel-From, J.
- Moore, A.Z.
- Murabito, J.M.
- Ollikainen, M.
- Pankow, J.S.
- Pedersen, N.L.
- Peters, A.
- Polidoro, S.
- Porteous, D.J.
- Raitakari, O.
- Rich, S.S.
- Sandler, D.P.
- Sillanpää, E.
- Smith, A.K.
- Southey, M.C.
- Strauch, K.
- Tiwari, H.
- Tanaka, T.
- Tillin, T.
- Uitterlinden, A.G.
- Van Den Berg, D.J.
- van Dongen, J.
- Wilson, J.G.
- Wright, J.
- Yet, I.
- Arnett, D.
- Bandinelli, S.
- Bell, J.T.
- Binder, A.M.
- Boomsma, D.I.
- Chen, W.
- Christensen, K.
- Conneely, K.N.
- Elliott, P.
- Ferrucci, L.
- Fornage, M.
- Hägg, S.
- Hayward, C.
- Irvin, M.R.
- Kaprio, J.
- Lawlor, D.A.
- Lehtimäki, T.
- Lohoff, F.W.
- Milani, L.
- Milne, R.L.
- Probst-Hensch, N.
- Reiner, A.P.
- Ritz, B.
- Rotter, J.I.
- Smith, J.A.
- Taylor, J.A.
- van Meurs, J.B.J.
- Vineis, P.
- Waldenberger, M.
- Deary, I.J.
- Relton, C.L.
- Horvath, S.
- Marioni, R.E.
DOIAbstract
BACKGROUND: Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. RESULTS: Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci associated with the Horvath clock and expression of transcrip...
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