Vitamin C u neuropsihijatriji

Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain. Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer's disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C.Vitamin su neophodni faktori za razvoj i normalnu funkciju mozga kod ljudi. Vitamin C je hidrosolubilno jedinjenje koje ljudski organizam ne može da sintetiše tako da smo potpuno zavisni od unosa putem hrane. Askorbinska kiselina je važno antioksidativno sredstvo i prisutna je u neuronima u visokim koncentracijama. Takođe je od ključnog značaja za sintezu kolagena u celom organizmu. Askorbinska kiselina ima ulogu u modulaciji mnogih bitnih neurotransmitera, omogućava neurogenezu u mozgu odraslog i štiti ćelije od infekcije. Dok SVCT1 omogućava apsorpciju vitamina C u crevima, SVCT2 se nalazi uglavnom u mozgu. Nedostatak askorbata klasično se ispoljava kao skorbut koji je letalan ako se ne leči, ali je supklinička deficijencija verovatno mnogo češća. Potencijalni terapijski domeni vitamina C terapije su neurodegenerativne, cerebrovaskularne i afektivne bolesti, karcinomi, traume mozga i drugi. Postoje na primer podaci o pozitivnim efektima askorbinske kiseline u Alchajmerovoj bolesti. Koriste se razni režimi doziranja, ali je askorbat pokazao bezbednost čak i u visokim dozama tokom dugih perioda. Potrebne su bolje dizajnirane studije da se razjasne sve potencijalne terapijske uloge vitamina C