Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD/Hyper-CMAD plus dasatinib or Hyper-CVAD plus ponatinib

Sasaki, Yuya, MD, PhD
Kantarjian, Hagop, MD
Short, Nicholas J., MD
Ravandi, Farhad, MD
Konopleva, Marina, MD, PhD
Garcia-Manero, Guillermo, MD
Futreal, PAndrew, PhD
Wang, Feng
Takahashi, Koichi, MD, PhD
Jabbour, Elias, MD

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Publication date

April 2021

Publisher

OpenWorks @ MD Anderson

Language

English

Abstract

Department of Leukemia Research Department of Leukemia Department of Genomic Medicinehttps://openworks.mdanderson.org/edwk21/1004/thumbnail.jp

Extracted data

Topics

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Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD/Hyper-CMAD plus dasatinib or Hyper-CVAD plus ponatinib

Sasaki, Yuya, MD, PhD
Kantarjian, Hagop, MD
Short, Nicholas J., MD
Ravandi, Farhad, MD
Konopleva, Marina, MD, PhD
Garcia-Manero, Guillermo, MD
Futreal, PAndrew, PhD
Wang, Feng
Takahashi, Koichi, MD, PhD
Jabbour, Elias, MD

Open PDF

Open link

Publication date

April 2021

Publisher

OpenWorks @ MD Anderson

Language

English

Abstract

Department of Leukemia Research Department of Leukemia Department of Genomic Medicinehttps://openworks.mdanderson.org/edwk21/1004/thumbnail.jp

Extracted data

Topics

Roberts, K.
Morin, R.
Zhang, J.
Hirst, M.
Zhao, Y.
Su, X.
Chen, S.
Payne-Turner, D.
Churchman, M.
Harvey, R.
Chen, X.
Kasap, C.
Yan, C.
Becksfort, J.
Finney, R.
Teachey, D.
Maude, S.
Tse, K.
Moore, R.
Jones, S.
et al.

January 2012

Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B...

Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD/Hyper-CMAD plus dasatinib or Hyper-CVAD plus ponatinib

Sasaki, Yuya, MD, PhD
Kantarjian, Hagop, MD
Short, Nicholas J., MD
Ravandi, Farhad, MD
Konopleva, Marina, MD, PhD
Garcia-Manero, Guillermo, MD
Futreal, PAndrew, PhD
Wang, Feng
Takahashi, Koichi, MD, PhD
Jabbour, Elias, MD

April 2021

Department of Leukemia Research Department of Leukemia Department of Genomic Medicinehttps://openwor...

HIGH-RESOLUTION PHARMACOGENETIC PROFILES OF GENES INVOLVED IN DRUG ABSORPTION, DISTRIBUTION, METABOLISM AND ELIMINATION IN ADULT PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS

IACOBUCCI, ILARIA
LONETTI, ANNALISA
SAZZINI, MARCO
FORMICA, SERENA
PAPAYANNIDIS, CRISTINA
ASTOLFI, ANNALISA
PAOLINI, STEFANIA
SOVERINI, SIMONA
MARTINELLI, GIOVANNI
A. Ferrari
GARAGNANI, PAOLO
BOATTINI, ALESSIO
D. Cilloni
MC Abbenante
V. Guadaguolo
A. Vitale
F. Pane
M. Vignetti
R. Foà
M. Baccarani

January 2010

Background: Inter-individual variations in genes encoding drug metabolizing enzymes and transporters...

Hyper‐CVAD plus ponatinib versus hyper‐CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia: A propensity score analysis

Sasaki, Koji
Jabbour, Elias J
Ravandi, Farhad
Short, Nicholas J
Thomas, Deborah A
Garcia‐Manero, Guillermo
Daver, Naval G
Kadia, Tapan M
Konopleva, Marina Y
Jain, Nitin
Issa, Ghayas C
Jeanis, Vicki
Moore, Haim G
Garris, Rebecca S
Pemmaraju, Naveen
Cortes, Jorge E
O'Brien, Susan M
Kantarjian, Hagop M

December 2016

BackgroundThe clinical efficacy of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and...

High frequency and poor outcome of Philadelphia chromosome-like acute lymphoblastic leukemia in adults

Roberts, K.G.
Gu, Z.
Payne-Turner, D.
McCastlain, K.
Harvey, R.C.
Chen, I.-M.
Pei, D.
Iacobucci, I.
Valentine, M.
Pounds, S.B.
Shi, L.
Li, Y.
Zhang, J.
Cheng, C.
Rambaldi, A.
Tosi, M.
Spinelli, O.
Radich, J.P.
Minden, M.D.
Rowe, J.M.
et al.

January 2017

Purpose: Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtyp...

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Fedullo AL
Messina M
Elia L
Piciocchi A
Gianfelici V
Lauretti A
Soddu S
Puzzolo MC
Minotti C
Ferrara F
Martino B
Chiusolo P (ORCID:0000-0002-1355-1587)
Calafiore V
Paolini S
Vignetti M
Vitale A
Guarini A
Foà R
Chiaretti S.

January 2019

To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leuke...

High-resolution genomic profiling of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) patients identified novel recurrent copy number variations involved in both pathogenesis and resistance to tyrosine kinase inhibitors

Iacobucci, Ilaria
Ottaviani, Emanuela
Astolfi, Annalisa
Francesco De Rosa,
Testoni, Nicoletta
Storlazzi, Tiziana
Impera, Luciana
Soverini, Simona
Paolini, Stefania
Papayannidis, Cristina
Giannoulia, Panagiota
Cilloni, Daniela
Pane, Fabrizio
Vitale, Antonella
Foa, Robin
Baccarani, Michele
Martinelli, Giovanni
LONETTI, ANNALISA
PESSION, ANDREA

January 2008

Background: The Ph chromosome is the most frequent karyotypic aberration in adults with ALL and it r...

A POLYMORPHISM IN THE CHROMOSOME 9P21 ANRIL LOCUS IS ASSOCIATED TO PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA SUSCEPTIBILITY

IACOBUCCI, ILARIA
SAZZINI, MARCO
LONETTI, ANNALISA
PAPAYANNIDIS, CRISTINA
ABBENANTE, MARIACHIARA
OTTAVIANI, EMANUELA
PAOLINI, STEFANIA
SOVERINI, SIMONA
MARTINELLI, GIOVANNI
Ferrari A
BOATTINI, ALESSIO
GARAGNANI, PAOLO
Mantovani V
MARASCO, ELENA
Guadagnuolo V
Girelli D
Vignetti M
Pane F
Baccarani M

January 2010

Introduction. Little is known about alterations of cyclin dependent kinase inhibitors p15INK4B, p16I...

Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias

Cortes, Jorge E
Kantarjian, Hagop
Shah, Neil P
Bixby, Dale
Mauro, Michael J
Flinn, Ian
O'Hare, Thomas
Hu, Simin
Narasimhan, Narayana I
Rivera, Victor M
Clackson, Tim
Turner, Christopher D
Haluska, Frank G
Druker, Brian J
Deininger, Michael WN
Talpaz, Moshe

November 2012

BackgroundResistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML) a...

THE RS564398, A POLYMORPHISM IN “THE ANTISENSE NON-CODING RNA IN THE INK4 LOCUS”, ANRIL, IS ASSOCIATED TO PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) SUSCEPTIBILITY

A. Ferrari
BOATTINI, ALESSIO
GARAGNANI, PAOLO
MC Abbenante
V. Mantovani
MARASCO, ELENA
D. Girelli
M. Vignetti
F. Pane
M. Baccarani
IACOBUCCI, ILARIA
SAZZINI, MARCO
LONETTI, ANNALISA
PAPAYANNIDIS, CRISTINA
CATTINA, FEDERICA
OTTAVIANI, EMANUELA
PAOLINI, STEFANIA
SOVERINI, SIMONA
MARTINELLI, GIOVANNI

January 2011

Introduction: Little is known about alterations of cyclin dependent kinase inhibitors p15INK4B, p16I...

Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: long-term follow-up of a single-centre, phase 2 study

Jabbour, Elias
Short, Nicholas J
Ravandi, Farhad
Huang, Xuelin
Daver, Naval
DiNardo, Courtney D
Konopleva, Marina
Pemmaraju, Naveen
Wierda, William
Garcia-Manero, Guillermo
Sasaki, Koji
Cortes, Jorge
Garris, Rebecca
Khoury, Joseph D
Jorgensen, Jeffrey
Jain, Nitin
Alvarez, Joie
O'Brien, Susan
Kantarjian, Hagop

December 2018

BackgroundThe combination of chemotherapy and ponatinib in Philadelphia chromosome-positive acute ly...

A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias

Cortes, JE
Kim, D-W
Pinilla-Ibarz, J
le Coutre, P
Paquette, R
Chuah, C
Nicolini, FE
Apperley, JF
Khoury, HJ
Talpaz, M
DiPersio, J
DeAngelo, DJ
Abruzzese, E
Rea, D
Baccarani, M
Müller, MC
Gambacorti-Passerini, C
Wong, S
Lustgarten, S
Rivera, VM
Clackson, T
Turner, CD
Haluska, FG
Guilhot, F
Deininger, MW
Hochhaus, A
Hughes, T
Goldman, JM
Shah, NP
Kantarjian, H

November 2013

BackgroundPonatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, inc...

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report

Martinelli, Giovanni
I., Iacobucci
C. T., Storlazzi
Vignetti, Marco
F., Paoloni
D., Cilloni
S., Soverini
A., Vitale
Chiaretti, Sabina
Cimino, Giuseppe
C., Papayannidis
S., Paolini
L., Elia
P., Fazi
Meloni, Giovanna
S., Amadori
G., Saglio
F., Pane
M., Baccarani
Foa, Roberto

January 2009

Purpose: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia...

Genetic alterations activating kinase and cytokine Receptor signaling in high-risk acute lymphoblastic leukemia

Roberts, K.
Morin, R.
Zhang, J.
Hirst, M.
Zhao, Y.
Su, X.
Chen, S.
Payne-Turner, D.
Churchman, M.
Harvey, R.
Chen, X.
Kasap, C.
Yan, C.
Becksfort, J.
Finney, R.
Teachey, D.
Maude, S.
Tse, K.
Moore, R.
Jones, S.
et al.

January 2012

Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B...

Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD/Hyper-CMAD plus dasatinib or Hyper-CVAD plus ponatinib

Sasaki, Yuya, MD, PhD
Kantarjian, Hagop, MD
Short, Nicholas J., MD
Ravandi, Farhad, MD
Konopleva, Marina, MD, PhD
Garcia-Manero, Guillermo, MD
Futreal, PAndrew, PhD
Wang, Feng
Takahashi, Koichi, MD, PhD
Jabbour, Elias, MD

April 2021

Department of Leukemia Research Department of Leukemia Department of Genomic Medicinehttps://openwor...

HIGH-RESOLUTION PHARMACOGENETIC PROFILES OF GENES INVOLVED IN DRUG ABSORPTION, DISTRIBUTION, METABOLISM AND ELIMINATION IN ADULT PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS

IACOBUCCI, ILARIA
LONETTI, ANNALISA
SAZZINI, MARCO
FORMICA, SERENA
PAPAYANNIDIS, CRISTINA
ASTOLFI, ANNALISA
PAOLINI, STEFANIA
SOVERINI, SIMONA
MARTINELLI, GIOVANNI
A. Ferrari
GARAGNANI, PAOLO
BOATTINI, ALESSIO
D. Cilloni
MC Abbenante
V. Guadaguolo
A. Vitale
F. Pane
M. Vignetti
R. Foà
M. Baccarani

January 2010

Background: Inter-individual variations in genes encoding drug metabolizing enzymes and transporters...

Hyper‐CVAD plus ponatinib versus hyper‐CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia: A propensity score analysis

Sasaki, Koji
Jabbour, Elias J
Ravandi, Farhad
Short, Nicholas J
Thomas, Deborah A
Garcia‐Manero, Guillermo
Daver, Naval G
Kadia, Tapan M
Konopleva, Marina Y
Jain, Nitin
Issa, Ghayas C
Jeanis, Vicki
Moore, Haim G
Garris, Rebecca S
Pemmaraju, Naveen
Cortes, Jorge E
O'Brien, Susan M
Kantarjian, Hagop M

December 2016

BackgroundThe clinical efficacy of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and...

High frequency and poor outcome of Philadelphia chromosome-like acute lymphoblastic leukemia in adults

Roberts, K.G.
Gu, Z.
Payne-Turner, D.
McCastlain, K.
Harvey, R.C.
Chen, I.-M.
Pei, D.
Iacobucci, I.
Valentine, M.
Pounds, S.B.
Shi, L.
Li, Y.
Zhang, J.
Cheng, C.
Rambaldi, A.
Tosi, M.
Spinelli, O.
Radich, J.P.
Minden, M.D.
Rowe, J.M.
et al.

January 2017

Purpose: Philadelphia chromosome (Ph) -like acute lymphoblastic leukemia (ALL) is a high-risk subtyp...

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Fedullo AL
Messina M
Elia L
Piciocchi A
Gianfelici V
Lauretti A
Soddu S
Puzzolo MC
Minotti C
Ferrara F
Martino B
Chiusolo P (ORCID:0000-0002-1355-1587)
Calafiore V
Paolini S
Vignetti M
Vitale A
Guarini A
Foà R
Chiaretti S.

January 2019

To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leuke...

Iacobucci, Ilaria
Ottaviani, Emanuela
Astolfi, Annalisa
Francesco De Rosa,
Testoni, Nicoletta
Storlazzi, Tiziana
Impera, Luciana
Soverini, Simona
Paolini, Stefania
Papayannidis, Cristina
Giannoulia, Panagiota
Cilloni, Daniela
Pane, Fabrizio
Vitale, Antonella
Foa, Robin
Baccarani, Michele
Martinelli, Giovanni
LONETTI, ANNALISA
PESSION, ANDREA

January 2008

Background: The Ph chromosome is the most frequent karyotypic aberration in adults with ALL and it r...

A POLYMORPHISM IN THE CHROMOSOME 9P21 ANRIL LOCUS IS ASSOCIATED TO PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA SUSCEPTIBILITY

IACOBUCCI, ILARIA
SAZZINI, MARCO
LONETTI, ANNALISA
PAPAYANNIDIS, CRISTINA
ABBENANTE, MARIACHIARA
OTTAVIANI, EMANUELA
PAOLINI, STEFANIA
SOVERINI, SIMONA
MARTINELLI, GIOVANNI
Ferrari A
BOATTINI, ALESSIO
GARAGNANI, PAOLO
Mantovani V
MARASCO, ELENA
Guadagnuolo V
Girelli D
Vignetti M
Pane F
Baccarani M

January 2010

Introduction. Little is known about alterations of cyclin dependent kinase inhibitors p15INK4B, p16I...

Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias

Cortes, Jorge E
Kantarjian, Hagop
Shah, Neil P
Bixby, Dale
Mauro, Michael J
Flinn, Ian
O'Hare, Thomas
Hu, Simin
Narasimhan, Narayana I
Rivera, Victor M
Clackson, Tim
Turner, Christopher D
Haluska, Frank G
Druker, Brian J
Deininger, Michael WN
Talpaz, Moshe

November 2012

BackgroundResistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia (CML) a...

THE RS564398, A POLYMORPHISM IN “THE ANTISENSE NON-CODING RNA IN THE INK4 LOCUS”, ANRIL, IS ASSOCIATED TO PHILADELPHIA POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) SUSCEPTIBILITY

A. Ferrari
BOATTINI, ALESSIO
GARAGNANI, PAOLO
MC Abbenante
V. Mantovani
MARASCO, ELENA
D. Girelli
M. Vignetti
F. Pane
M. Baccarani
IACOBUCCI, ILARIA
SAZZINI, MARCO
LONETTI, ANNALISA
PAPAYANNIDIS, CRISTINA
CATTINA, FEDERICA
OTTAVIANI, EMANUELA
PAOLINI, STEFANIA
SOVERINI, SIMONA
MARTINELLI, GIOVANNI

January 2011

Introduction: Little is known about alterations of cyclin dependent kinase inhibitors p15INK4B, p16I...

Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: long-term follow-up of a single-centre, phase 2 study

Jabbour, Elias
Short, Nicholas J
Ravandi, Farhad
Huang, Xuelin
Daver, Naval
DiNardo, Courtney D
Konopleva, Marina
Pemmaraju, Naveen
Wierda, William
Garcia-Manero, Guillermo
Sasaki, Koji
Cortes, Jorge
Garris, Rebecca
Khoury, Joseph D
Jorgensen, Jeffrey
Jain, Nitin
Alvarez, Joie
O'Brien, Susan
Kantarjian, Hagop

December 2018

BackgroundThe combination of chemotherapy and ponatinib in Philadelphia chromosome-positive acute ly...

A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias

Cortes, JE
Kim, D-W
Pinilla-Ibarz, J
le Coutre, P
Paquette, R
Chuah, C
Nicolini, FE
Apperley, JF
Khoury, HJ
Talpaz, M
DiPersio, J
DeAngelo, DJ
Abruzzese, E
Rea, D
Baccarani, M
Müller, MC
Gambacorti-Passerini, C
Wong, S
Lustgarten, S
Rivera, VM
Clackson, T
Turner, CD
Haluska, FG
Guilhot, F
Deininger, MW
Hochhaus, A
Hughes, T
Goldman, JM
Shah, NP
Kantarjian, H

November 2013

BackgroundPonatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, inc...

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report

Martinelli, Giovanni
I., Iacobucci
C. T., Storlazzi
Vignetti, Marco
F., Paoloni
D., Cilloni
S., Soverini
A., Vitale
Chiaretti, Sabina
Cimino, Giuseppe
C., Papayannidis
S., Paolini
L., Elia
P., Fazi
Meloni, Giovanna
S., Amadori
G., Saglio
F., Pane
M., Baccarani
Foa, Roberto

January 2009

Purpose: The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia...

Genetic alterations activating kinase and cytokine Receptor signaling in high-risk acute lymphoblastic leukemia

Roberts, K.
Morin, R.
Zhang, J.
Hirst, M.
Zhao, Y.
Su, X.
Chen, S.
Payne-Turner, D.
Churchman, M.
Harvey, R.
Chen, X.
Kasap, C.
Yan, C.
Becksfort, J.
Finney, R.
Teachey, D.
Maude, S.
Tse, K.
Moore, R.
Jones, S.
et al.

January 2012

Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B...

Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD/Hyper-CMAD plus dasatinib or Hyper-CVAD plus ponatinib

Abstract

Extracted data

Topics

Genetic correlates in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with Hyper-CVAD/Hyper-CMAD plus dasatinib or Hyper-CVAD plus ponatinib

Abstract

Extracted data

Topics

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