Ly6Chi inflammatory monocytes develop in the bone marrow and migrate to the site of infection during inflammation. Upon recruitment, Ly6Chi monocytes can differentiate into dendritic cells or macrophages. According to the tissue environment they can also acquire different functions. Several studies have described pre-activation of Ly6Chi monocytes in the bone marrow during parasitic infection, but whether this process occurs during experimental visceral leishmaniasis and, if so, the mechanisms contributing to their activation are yet to be established. In wild type C57BL/6 (B6) mice infected with Leishmania donovani, the number of bone marrow Ly6Chi monocytes increased over time. Ly6Chi monocytes displayed a highly activated phenotype from ...
A protective immune response against Leishmania donovani infection is mediated by T-helper type 1 (T...
Activated natural killer (NK) cells release interferon (IFN)-γ, which is crucial for the control of ...
Infections in mice with Leishmania major are used to study Th cell subset development and regulation...
Ly6Chi inflammatory monocytes develop in the bone marrow and migrate to the site of infection during...
Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone mar...
Hematopoietic stem/progenitor cells (HSPC) are responsible for the generation of most immune cells t...
<div><p>Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the ...
Visceral leishmaniasis is associated with significant changes in hematological function but the mech...
Ly6Chi inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria ...
Leishmania major infection induces self-healing cutaneous lesions in C57BL/6 mice. Both IL-12 and IF...
SummaryInfection-induced inflammatory reactions involve a strong increase in dendritic cells (DCs) a...
<p>Freshly isolated lineage-depleted <i>Fzd6</i><sup>+/+</sup> (WT) BM cells were cultured in comple...
Dendritic cells (DCs), instructed by the priming signals from microbial factors, can produce interle...
Leishmania are obligate intracellular parasites of monocytes, that may cause systemic disease or ski...
The onset of Th1 immunity is in part regulated by genetic background. To elucidate the cell type car...
A protective immune response against Leishmania donovani infection is mediated by T-helper type 1 (T...
Activated natural killer (NK) cells release interferon (IFN)-γ, which is crucial for the control of ...
Infections in mice with Leishmania major are used to study Th cell subset development and regulation...
Ly6Chi inflammatory monocytes develop in the bone marrow and migrate to the site of infection during...
Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone mar...
Hematopoietic stem/progenitor cells (HSPC) are responsible for the generation of most immune cells t...
<div><p>Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the ...
Visceral leishmaniasis is associated with significant changes in hematological function but the mech...
Ly6Chi inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria ...
Leishmania major infection induces self-healing cutaneous lesions in C57BL/6 mice. Both IL-12 and IF...
SummaryInfection-induced inflammatory reactions involve a strong increase in dendritic cells (DCs) a...
<p>Freshly isolated lineage-depleted <i>Fzd6</i><sup>+/+</sup> (WT) BM cells were cultured in comple...
Dendritic cells (DCs), instructed by the priming signals from microbial factors, can produce interle...
Leishmania are obligate intracellular parasites of monocytes, that may cause systemic disease or ski...
The onset of Th1 immunity is in part regulated by genetic background. To elucidate the cell type car...
A protective immune response against Leishmania donovani infection is mediated by T-helper type 1 (T...
Activated natural killer (NK) cells release interferon (IFN)-γ, which is crucial for the control of ...
Infections in mice with Leishmania major are used to study Th cell subset development and regulation...