Smoking, Hypertension, and GG Genotype of the IL-6 rs1800796 Polymorphism are Independent Risk Factors for Abdominal Aortic Aneurysm in Han Population

Yuchao Zhang, Gang Xu, Ping Wang Department of Vascular Surgery, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian City, 223300, People’s Republic of ChinaCorrespondence: Ping Wang Tel/Fax +86-0517-80872149Email drwangping@126.comBackground: Recent researches have investigated the link between the rs1800796 polymorphism (− 572G/C) in the interleukin-6 (IL-6) gene and the risk of abdominal aortic aneurysm (AAA). However, no Chinese studies have addressed the association between the risk of AAA and this polymorphism.Methods: This case-control study included 153 AAA patients and 205 controls. Diabetes mellitus, hypertension, dyslipidemia, and coronary artery disease (CAD) status were collected. The AAA and control groups were 69.20 ± 7.56 and 68.50 ± 7.12 years old, respectively.Results: The analysis revealed that the G allele and GG genotype of the IL-6 rs1800796 polymorphism were remarkedly correlated with an elevated risk of AAA. The GG genotype displayed an association with the risk of AAA after adjustment for gender, body mass index, age, drinking, and smoking. Subgroup analyses indicated that this polymorphism elevated the risk of AAA among males, individuals aged ≥ 70 years, smokers, drinkers, individuals with a body mass index (BMI) ≥ 25 kg/m2, patients without diabetes, and patients with hypertension. Univariate and multivariate analyses indicated that smoking, hypertension, and the GG genotype (rs1800796 polymorphism) were independently related with the risk of AAA.Conclusion: The IL-6 rs1800796 polymorphism increases the risk of AAA. In addition, smoking, hypertension, and the GG genotype of the rs1800796 polymorphism are independent risk factors for AAA. Further studies of Chinese populations are needed to validate these findings.Keywords: IL-6, abdominal aortic aneurysm, rs1800796 polymorphism, risk factor