In healthy neurons, a mitochondrial membrane potential gradient exists whereby membrane potential is highest in the soma and decreases with distance from the nucleus. Correspondingly, distal mitochondria have more oxidative damage and slower protein import than somal mitochondria. Due to these differences, distal mitochondria have an intrinsic first stressor that somal mitochondria do not have, resulting in synaptic mitochondrial vulnerability.A second stressor may result from mutant protein expression, situational stress, or aging, exacerbating vulnerable mitochondria activating stress responses. Under these conditions, distal mitochondria release cytochrome c and mitochondrial DNA, leading to compartmentalized sub-lethal caspase-3 activat...
AbstractNeurones undergo diverse forms of cell death depending on the nature and severity of the str...
Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of learning ...
Neurones undergo diverse forms of cell death depending on the nature and severity of the stress. The...
Mitochondria are critical in providing energy for neuronal development. They provide the majority of...
Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondria...
Mitochondria are organelles that are present in all nucleated cells in the body. They have manifold ...
Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondria...
Mitochondria play a multidimensional role in the function and the vitality of the neurological syste...
Mitochondrial electron transport generates the ATP that is essential for the excitability and surviv...
Mitochondria are the primary generators of ATP and are important regulators of intracellular calcium...
Efforts to understand how mitochondrial dysfunction contributes to neurode-generation have primarily...
open access articleMitochondria - nuclear coadaptation has been central to eukaryotic evolution. The...
Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are the m...
Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate...
Abstract The sustained integrity of the mitochondrial population of a cell is critical for maintaine...
AbstractNeurones undergo diverse forms of cell death depending on the nature and severity of the str...
Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of learning ...
Neurones undergo diverse forms of cell death depending on the nature and severity of the stress. The...
Mitochondria are critical in providing energy for neuronal development. They provide the majority of...
Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondria...
Mitochondria are organelles that are present in all nucleated cells in the body. They have manifold ...
Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondria...
Mitochondria play a multidimensional role in the function and the vitality of the neurological syste...
Mitochondrial electron transport generates the ATP that is essential for the excitability and surviv...
Mitochondria are the primary generators of ATP and are important regulators of intracellular calcium...
Efforts to understand how mitochondrial dysfunction contributes to neurode-generation have primarily...
open access articleMitochondria - nuclear coadaptation has been central to eukaryotic evolution. The...
Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are the m...
Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate...
Abstract The sustained integrity of the mitochondrial population of a cell is critical for maintaine...
AbstractNeurones undergo diverse forms of cell death depending on the nature and severity of the str...
Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of learning ...
Neurones undergo diverse forms of cell death depending on the nature and severity of the stress. The...