Primary aldosteronism is the most common form of secondary hypertension and induces various cardiovascular injuries. In aldosterone-producing adenoma (APA), the impact of KCNJ5 somatic mutations on arterial stiffness excluding the influence of confounding factors is uncertain. We enrolled 213 APA patients who were scheduled to undergo adrenalectomy. KCNJ5 gene sequencing of APA was performed. After propensity score matching (PSM) for age, sex, body mass index, blood pressure, number of hypertensive medications, and hypertension duration, there were 66 patients in each group with and without KCNJ5 mutations. The mutation carriers had a higher aldosterone level and lower log transformed brachial–ankle pulse wave velocity (baPWV) than the non-...
Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account...
Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is nec...
International audienceCONTEXT: Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 hav...
Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene...
Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene...
OBJECTIVE:: Aldosterone exerts detrimental cardiovascular effects, and patients with an aldosterone-...
Hypertension due to primary aldosteronism poses a risk of severe cardiovascular complications compar...
Context: Somatic mutations in the selectivity filter of KCNJ5 K+ channel were found to be associated...
Background: Aldosterone producing lesions are a common cause of hypertension, but genetic alteration...
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovasc...
Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumori...
Context:Somatic mutations in the selectivity filter of KCNJ5 K(+) channel were found to be associate...
A new report in Science finds that a few somaticKCNJ5 mutations explain a subset of aldosterone-prod...
OBJECTIVES:Recently, somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes were found to be ...
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5,...
Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account...
Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is nec...
International audienceCONTEXT: Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 hav...
Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene...
Primary aldosteronism is the most common form of secondary hypertension. Mutations in the KCNJ5 gene...
OBJECTIVE:: Aldosterone exerts detrimental cardiovascular effects, and patients with an aldosterone-...
Hypertension due to primary aldosteronism poses a risk of severe cardiovascular complications compar...
Context: Somatic mutations in the selectivity filter of KCNJ5 K+ channel were found to be associated...
Background: Aldosterone producing lesions are a common cause of hypertension, but genetic alteration...
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovasc...
Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumori...
Context:Somatic mutations in the selectivity filter of KCNJ5 K(+) channel were found to be associate...
A new report in Science finds that a few somaticKCNJ5 mutations explain a subset of aldosterone-prod...
OBJECTIVES:Recently, somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes were found to be ...
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5,...
Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account...
Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is nec...
International audienceCONTEXT: Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 hav...