International audienceContext. The evolution of galaxies depends on their interaction with the surrounding environment. Ultra-diffuse galaxies (UDGs) have been found in large numbers in clusters. We detected a few star-forming blobs in the VESTIGE survey, located at ∼5 kpc from a UDG, namely NGVS 3543, in association with an HI gas cloud AGC 226178, suggesting a recent interaction between this low-surface-brightness system and the surrounding cluster environment.Aims. We use a complete set of multi-frequency data including deep optical, UV, and narrow-band Hα imaging and HI data to understand the formation process that gave birth to this peculiar system.Methods. For this purpose, we measured (i) the multi-wavelength radial surface brightnes...