International audienceContext. For several years, Jupiter-family comets have been the targets of spacecraft missions whose aims are to determine the comets' composition, structure, and physical properties. The Rosetta mission is currently flying towards comet 67P/Churyumov Gerasimenko for a rendezvous in August 2014 and comet 46P/Wirtanen is considered for a rendezvous in 2021 with the PriME (Primitive Material Explorer) mission, which is currently proposed to NASA.Aims: Here we investigate the stability conditions of clathrate hydrates within the comets 67P/Churyumov-Gerasimenko and 46P/Wirtanen by considering an initial mixture of amorphous H2O with CO, CO2, CH4, and H2S in the nuclei.Methods: We use a one-dimensional nucleus model, which...