Add to ORKGAdvisors: James R. Horn.Committee members: Gary Baker; Timothy Hagen; Victor Ryzhov; Yanbin Yin.Antibody fragments are attractive alternatives to conventional antibodies for both therapeutic and diagnostic applications. One example, single-domain VHH antibodies, which are derived from camelid heavy chain-only antibodies, display comparable binding affinity to conventional antibodies despite the significantly reduced binding interface. Here, an anti-RNase A VHH single-domain antibody and its antigen, RNase A, are used as a model antibody-antigen system for the three studies described in this dissertation.Ph.D. (Doctor of Philosophy
Thesis (Ph.D.)--University of Washington, 2018Antibody-based proteins have become an important class...
A llama single domain antibody (dAb) library designed and constructed to contain only heavy chain an...
Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the cl...
AbstractBackground: Camelid serum contains a large fraction of functional heavy-chain antibodies – h...
Antibodies and antibody-fragments have emerged as promising tools for many therapeutic and biotechno...
Monoclonal antibodies are a remarkably successful class of therapeutics used to treat a wide range o...
Monoclonal antibodies have revolutionised the biomedical field through their ubiquitous utilisation ...
The number of therapeutic antibodies in preclinical, clinical, or approved phases has been increasin...
Abstract The high binding affinities and specificities of antibodies have led to their use as drugs ...
Since the discovery of camelid heavy chain-only antibodies (HCAbs) in 1993 and shark immunoglobulin ...
The hypervariable loops of an antibody molecule are supported on the relatively conserved β-sheeted ...
The immune system is an important part of the physiology of higher organisms. In the immune system a...
Antibodies and antibody fragments are essential tools in basic research, diagnostics and therapy. Co...
5To whom correspondence should be addressed Although the heavy and light chain domains of some antib...
Antibodies are important tools for experimental research and medical applications. Most antibodies a...
Thesis (Ph.D.)--University of Washington, 2018Antibody-based proteins have become an important class...
A llama single domain antibody (dAb) library designed and constructed to contain only heavy chain an...
Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the cl...
AbstractBackground: Camelid serum contains a large fraction of functional heavy-chain antibodies – h...
Antibodies and antibody-fragments have emerged as promising tools for many therapeutic and biotechno...
Monoclonal antibodies are a remarkably successful class of therapeutics used to treat a wide range o...
Monoclonal antibodies have revolutionised the biomedical field through their ubiquitous utilisation ...
The number of therapeutic antibodies in preclinical, clinical, or approved phases has been increasin...
Abstract The high binding affinities and specificities of antibodies have led to their use as drugs ...
Since the discovery of camelid heavy chain-only antibodies (HCAbs) in 1993 and shark immunoglobulin ...
The hypervariable loops of an antibody molecule are supported on the relatively conserved β-sheeted ...
The immune system is an important part of the physiology of higher organisms. In the immune system a...
Antibodies and antibody fragments are essential tools in basic research, diagnostics and therapy. Co...
5To whom correspondence should be addressed Although the heavy and light chain domains of some antib...
Antibodies are important tools for experimental research and medical applications. Most antibodies a...
Thesis (Ph.D.)--University of Washington, 2018Antibody-based proteins have become an important class...
A llama single domain antibody (dAb) library designed and constructed to contain only heavy chain an...
Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the cl...