International audienceAlthough cellular prion protein PrPC is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, we here show that PrPC displays the intrinsic capacity to protect neuronal cells from a pro-inflammatory TNFα noxious insult. Mechanistically, PrPC coupling to the NADPH oxidase-TACE α-secretase signaling pathway promotes TACE-mediated cleavage of transmembrane TNFα receptors (TNFRs) and the release of soluble TNFR, which limits the sensitivity of recipient cells to TNFα. We further show that PrPC expression is necessary for TACE α-secretase to stay at the plasma membrane in an active state for TNFR shedding. Such PrPC control of TA...
The cellular prion protein (PrPC) is known for its pivotal role in the development of prion diseases...
Transmissible spongiform encephalopathies (TSEs) are rare, uniformly fatal neurodegenerative disord...
The accumulation of the scrapie prion protein PrPSc, a misfolded conformer of the cellular prion pro...
International audienceAlthough cellular prion protein PrPC is well known for its implication in Tran...
Prion diseases are rare and fatal neurodegenerative disorders that occur when the cellular prion pro...
International audiencealpha-secretase-mediated cleavage of amyloid precursor protein (APP) precludes...
α-secretase–mediated cleavage of amyloid precursor protein (APP) precludes formation of neurotoxic a...
The cellular prion protein (PrPC) is a medium-sized glycoprotein, attached to the cell surface by a ...
The conversion of cellular prion protein (PrPc), a GPI-anchored protein, into a protease-K-resistant...
International audienceThe cellular prion protein PrPc is the normal counterpart of the scrapie prion...
The cellular prion protein, PrPC, is a glycosylphosphatidylinositol anchored-membrane glycoprotein e...
Prion protein (PrPC) was originally known as the causative agent of transmissible spongiform encepha...
International audienceThe cellular prion protein PrP(C) was identified over twenty-five years ago as...
The cellular prion protein (PrPC) is a ubiquitous glycoprotein highly expressed in the brain where i...
International audienceBackground: Activation of glia in prion diseases contributes to TSE pathogenes...
The cellular prion protein (PrPC) is known for its pivotal role in the development of prion diseases...
Transmissible spongiform encephalopathies (TSEs) are rare, uniformly fatal neurodegenerative disord...
The accumulation of the scrapie prion protein PrPSc, a misfolded conformer of the cellular prion pro...
International audienceAlthough cellular prion protein PrPC is well known for its implication in Tran...
Prion diseases are rare and fatal neurodegenerative disorders that occur when the cellular prion pro...
International audiencealpha-secretase-mediated cleavage of amyloid precursor protein (APP) precludes...
α-secretase–mediated cleavage of amyloid precursor protein (APP) precludes formation of neurotoxic a...
The cellular prion protein (PrPC) is a medium-sized glycoprotein, attached to the cell surface by a ...
The conversion of cellular prion protein (PrPc), a GPI-anchored protein, into a protease-K-resistant...
International audienceThe cellular prion protein PrPc is the normal counterpart of the scrapie prion...
The cellular prion protein, PrPC, is a glycosylphosphatidylinositol anchored-membrane glycoprotein e...
Prion protein (PrPC) was originally known as the causative agent of transmissible spongiform encepha...
International audienceThe cellular prion protein PrP(C) was identified over twenty-five years ago as...
The cellular prion protein (PrPC) is a ubiquitous glycoprotein highly expressed in the brain where i...
International audienceBackground: Activation of glia in prion diseases contributes to TSE pathogenes...
The cellular prion protein (PrPC) is known for its pivotal role in the development of prion diseases...
Transmissible spongiform encephalopathies (TSEs) are rare, uniformly fatal neurodegenerative disord...
The accumulation of the scrapie prion protein PrPSc, a misfolded conformer of the cellular prion pro...