Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation centers utilize pancreases from extended criteria donors, such as from donation after circulatory death (DCD) donors, which are particularly susceptible to prolonged cold ischemia time (CIT). We hypothesized that hypothermic machine perfusion (HMP) can safely increase CIT. Five human DCD pancreases were subjected to 6 h of oxygenated HMP. Perfusion parameters, apoptosis, and edema were measured prior to islet isolation. Five human DBD pancreases were evaluated after static cold storage (SCS). Islet viability, and in vitro and in vivo functionality in diabetic mice were analyzed. Islets were isolated from HMP pancreases after 13.4 h [12.9-14.5] CI...
Background: Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to Unive...
Background: In the Netherlands approximately 100,000 patients are diagnosed with diabetes mellitus t...
Background. Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to Unive...
Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation cent...
Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation cent...
Background Transplantation of beta cells by pancreas or islet transplantation is the treatment of ch...
Background. Transplantation of beta cells by pancreas or islet transplantation is the treatment of c...
Islet transplantation has found its niche in diabetes treatment. It has contributed to a better qual...
Pancreas preservation by cold storage using University of Wisconsin solution was the mainstay metho...
Background: Pancreatic transplantation is the treatment of choice for a selected group of patients w...
Due to a shortage of donation after brain death (DBD) organs, donation after circulatory death (DCD)...
Successful pancreatic islet transplantation depends on the number of islets transplanted, islet via...
Currently, the only curative treatment option for patients with diabetes mellitus type 1 is the tran...
The results of islet transplantation have been significantly improved in recent years following majo...
Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients...
Background: Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to Unive...
Background: In the Netherlands approximately 100,000 patients are diagnosed with diabetes mellitus t...
Background. Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to Unive...
Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation cent...
Due to an increasing scarcity of pancreases with optimal donor characteristics, islet isolation cent...
Background Transplantation of beta cells by pancreas or islet transplantation is the treatment of ch...
Background. Transplantation of beta cells by pancreas or islet transplantation is the treatment of c...
Islet transplantation has found its niche in diabetes treatment. It has contributed to a better qual...
Pancreas preservation by cold storage using University of Wisconsin solution was the mainstay metho...
Background: Pancreatic transplantation is the treatment of choice for a selected group of patients w...
Due to a shortage of donation after brain death (DBD) organs, donation after circulatory death (DCD)...
Successful pancreatic islet transplantation depends on the number of islets transplanted, islet via...
Currently, the only curative treatment option for patients with diabetes mellitus type 1 is the tran...
The results of islet transplantation have been significantly improved in recent years following majo...
Pancreatic islet transplantation is a promising option for the treatment of type 1 diabetic patients...
Background: Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to Unive...
Background: In the Netherlands approximately 100,000 patients are diagnosed with diabetes mellitus t...
Background. Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to Unive...