The Influence of Micropatterned Surface on the Formation of Staphylococcus aureus Biofilm

Biofilms are complex aggregation of microorganisms grown on a solid substrate. They are characterized by structural heterogeneity, genetic diversity, and complex community interactions. Biofilm can be formed on a lot of surfaces including human body implants. When it is formed on the surface of implants, the consequence will be the removal of the implants, because biofilms are very resistant to antibodies. Biofilms are responsive and dynamic, and are adaptive to the changes of the environment. The cells in the biofilms are genetically different from the planktonic cells. In this work, I studied how microenvironment, specifically the micropattern of the surface's influences on the formation of the staphylococcus aureus biofilm. I found that micropatterned surface affected the thickness and the number of dead cells in the bioflm