Antimutagenicity potential of isolates from the Dichloromethane extract of Solanum nigrum

The leaves of Solanum nigrum were air dried, ground and soaked in dichloromethane. The dichloromethane extract afforded three isolates which were obtained by repeated gravity column chromatography, and monitored by thin layer chromatography. The three isolates were tested for antimutagenicity potential by the Micronucleus test. Results showed that TLC pure isolate A increased the number of micronucleated polychromatic erythrocytes (MPCE) induced by Mitomycin C by 34.87%. Thus, it is a mutagen. On the other hand, TLC pure isolates B and C reduced the number of MPCE by 11.58% and 67.50% respectively. Thus, both compounds are antimutagens