Diabetes Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Over half of childhood Acute Lymphoblastic Leukemia (ALL) survivors will suffer from one or more treatment-related medical conditions in their lifetime, many of which are known risk factors for diabetes. This study aims to determine the prevalence and potential risk factors of diabetes among ALL survivors from the St. Jude Lifetime Cohort (SJLIFE). We performed a retrospective-cohort analysis of 1041 SJLIFE 10-year survivors of ALL compared to 368 controls. Risk factors associated with increased risk of type 2 diabetes (T2DM) in survivors included: drug-induced diabetes (OR 4.98, 95% CI 2.59-9.58), obese/overweight BMI (OR 7.02, 95% CI 2.45-20.07; OR 3.26, 95% CI 1.03-10.23), and increasing age (OR 1.04, 95% CI 1.01-1.08). Survivors were also more likely to suffer from pre-diabetes (OR 1.33, 95% CI 1.06-1.67) and T2DM (OR 2.03 95% CI 1.09-2.83) compared to controls, highlighting the importance of surveillance and early interventions in SJLIFE survivors of childhood ALL