Add to ORKGSickle Cell Disease (SCD) is one of the most common severe monogenic disorders in the world. The disease causes severe pain, inflammation, tissue ischemia, and bone damage. The Townes mouse model of SCD has been useful in studying many of the pathophysiologies of the disease but has not been evaluated as a model of SCD-induced bone abnormalities. The data presented in this study demonstrate that SCD causes bone abnormalities in the Townes mouse model similar to those present in humans. This study also evaluated the antioxidant agent N-acetyl-L-cysteine (NAC) as a potential therapeutic agent for the progression of bone abnormalities in SCD mice
(A) 3D μ-CT images of trabecular bone of distal femurs isolated from 5-week-old male WT and Prx1-Cre...
Cherubism is a human genetic disorder that affects children around the ages of 3-4 years. It causes ...
Since the development of knockout and transgenic mouse models, mice have become the most widely used...
Sickle Cell Disease (SCD) is one of the most severe, monogenic, autosomal recessive disorders in the...
Sickle cell disease (SCD) is a genetic hemoglobinopathy that has grown into a global health concern....
Sickle bone disease (SBD) is a chronic and invalidating complication of Sickle cell disease (SCD), a...
Sickle cell anemia (SCD) is a hemoglobinopathy caused by a single nucleotide mutation in the beta gl...
Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder, characterized by ...
Bone loss is a common complication in individuals with sickle cell disease (SCD). The mechanism(s) o...
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States. SCD affe...
Background: Krabbe disease, also known as globoid cell leukodystrophy, is an autosomal recessive neu...
Because Berkeley sickle cell mice are used as an animal model for human sickle cell disease, we inve...
<p>A. Reconstructed 3-dimensional micro-CT images of the tibia of naïve mice, mice bearing 5T2MM cel...
Introduction: The aim was to evaluate the structural and functional changes of bone tissue in mice w...
Bone defects resulting from non-unions, fractures, significant revision jointreplacements, tumour re...
(A) 3D μ-CT images of trabecular bone of distal femurs isolated from 5-week-old male WT and Prx1-Cre...
Cherubism is a human genetic disorder that affects children around the ages of 3-4 years. It causes ...
Since the development of knockout and transgenic mouse models, mice have become the most widely used...
Sickle Cell Disease (SCD) is one of the most severe, monogenic, autosomal recessive disorders in the...
Sickle cell disease (SCD) is a genetic hemoglobinopathy that has grown into a global health concern....
Sickle bone disease (SBD) is a chronic and invalidating complication of Sickle cell disease (SCD), a...
Sickle cell anemia (SCD) is a hemoglobinopathy caused by a single nucleotide mutation in the beta gl...
Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder, characterized by ...
Bone loss is a common complication in individuals with sickle cell disease (SCD). The mechanism(s) o...
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States. SCD affe...
Background: Krabbe disease, also known as globoid cell leukodystrophy, is an autosomal recessive neu...
Because Berkeley sickle cell mice are used as an animal model for human sickle cell disease, we inve...
<p>A. Reconstructed 3-dimensional micro-CT images of the tibia of naïve mice, mice bearing 5T2MM cel...
Introduction: The aim was to evaluate the structural and functional changes of bone tissue in mice w...
Bone defects resulting from non-unions, fractures, significant revision jointreplacements, tumour re...
(A) 3D μ-CT images of trabecular bone of distal femurs isolated from 5-week-old male WT and Prx1-Cre...
Cherubism is a human genetic disorder that affects children around the ages of 3-4 years. It causes ...
Since the development of knockout and transgenic mouse models, mice have become the most widely used...