Pseudouridylation refers to the isomerization of uridine to pseudouridine in RNA and is catalyzed by enzymes known as pseudouridine synthases. In eukaryotes, pseudouridylation of rRNA is primarily directed by a complex of proteins and a box H/ACA guide RNA. The guide RNA specifies a target by forming transient base pair interactions on either side of the target uridine, although other standalone pseudouridine synthases may employ different targeting mechanisms. With this project, we aim to modify naturally occurring guide RNAs to allow for specific targeting in a location different from the original. Pseudouridylation of a premature stop codon in mRNA results in translational readthrough and production of a functional protein. Here, we util...
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-generation seque...
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), th...
open5noAssociazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research: AIR...
Pseudouridylation refers to the isomerization of uridine to pseudouridine in RNA and is catalyzed by...
<div><p>We developed a novel technique, called pseudouridine site identification sequencing (PSI-seq...
Post-transcriptional modification of RNA nucleosides occurs in all living organisms. Pseudouridine, ...
International audienceSite-specific pseudouridylation of human ribosomal and spliceosomal RNAs is di...
SummaryPseudouridine is the most abundant RNA modification, yet except for a few well-studied cases,...
All three translation termination codons, or nonsense codons, contain a uridine residue at the first...
Pseudouridine is the most abundant RNA modification, yet except for a few well-studied cases, little...
The uridine to pseudouridine transformation, one of the most abundant and essential post-transcripti...
The isomerization of uridine to pseudouridine (W), known as pseudouridylation, is the most abundant ...
More than 100 different types of chemical modifications to RNA have been documented so far. Historic...
A common post-transcriptional modification of RNA is the conversion of uridine to its isomer pseudou...
The structure, stability, and function of various coding and noncoding RNAs are influenced by chemic...
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-generation seque...
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), th...
open5noAssociazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research: AIR...
Pseudouridylation refers to the isomerization of uridine to pseudouridine in RNA and is catalyzed by...
<div><p>We developed a novel technique, called pseudouridine site identification sequencing (PSI-seq...
Post-transcriptional modification of RNA nucleosides occurs in all living organisms. Pseudouridine, ...
International audienceSite-specific pseudouridylation of human ribosomal and spliceosomal RNAs is di...
SummaryPseudouridine is the most abundant RNA modification, yet except for a few well-studied cases,...
All three translation termination codons, or nonsense codons, contain a uridine residue at the first...
Pseudouridine is the most abundant RNA modification, yet except for a few well-studied cases, little...
The uridine to pseudouridine transformation, one of the most abundant and essential post-transcripti...
The isomerization of uridine to pseudouridine (W), known as pseudouridylation, is the most abundant ...
More than 100 different types of chemical modifications to RNA have been documented so far. Historic...
A common post-transcriptional modification of RNA is the conversion of uridine to its isomer pseudou...
The structure, stability, and function of various coding and noncoding RNAs are influenced by chemic...
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-generation seque...
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), th...
open5noAssociazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research: AIR...