Vaccinia is the model virus used to study the lifecycle of poxviruses, large DNA viruses that include agents of human disease such as smallpox and monkeypox. Unusual for DNA viruses, poxviruses replicate in the cytoplasm of the cell, autonomous from the nucleus. Because of this autonomy, the virus encodes a large number of genes devoted to replication and morphogenesis. The initial steps of morphogenesis, known as membrane biogenesis, remain unclear. The viral membrane is thought to originate from the endoplasmic reticulum; however, how the membrane is diverted from that organelle is currently not known. Various viral proteins have been identified as being vital to this process. We have been developing genetic tools to study the A30.5 and L...
Cyanobacteria are among the few microbes that have the ability to grow in elevated pH. The cyanobact...
CD4+ T cell responses are critical components of the immune response to viral infections, yet unlike...
Monoclonal antibodies are powerful and versatile tools that enable the study of proteins in diverse ...
Mutations in sweetpotato [Ipomoea batatas (L.) Lam.], which are poorly understood, are widely implic...
Bacteriophages (phages) are viruses that specifically parasitize on bacteria and are found almost ev...
Collagen VI is an extracellular matix protein that forms a microfilamentous network in skeletal musc...
Evidence suggests that 15-lipoxygenase-2 (15-LOX-2) plays an important role in the progression of at...
Delivery of lipophilic bioactives such as lutein and vitamin D into food products is challenging due...
Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne\u27s disease, a chronic progress...
In the last twenty years, interferon-α (IFN-α) has gained success as an immunotherapy for treating s...
Malignant pleural mesothelioma (MPM) is a highly aggressive tumour arising from the mesothelial cell...
Enumeration of bacteria has been the subject of research for over a century. Some of the techniques ...
Type 1 diabetes is the direct result of an autoimmune attack on the pancreatic islet cells. The isl...
The studies in this dissertation investigate neurodegenerative conditions of the central and periphe...
The expected growth of the older adult population in the United States over the next several decades...
Cyanobacteria are among the few microbes that have the ability to grow in elevated pH. The cyanobact...
CD4+ T cell responses are critical components of the immune response to viral infections, yet unlike...
Monoclonal antibodies are powerful and versatile tools that enable the study of proteins in diverse ...
Mutations in sweetpotato [Ipomoea batatas (L.) Lam.], which are poorly understood, are widely implic...
Bacteriophages (phages) are viruses that specifically parasitize on bacteria and are found almost ev...
Collagen VI is an extracellular matix protein that forms a microfilamentous network in skeletal musc...
Evidence suggests that 15-lipoxygenase-2 (15-LOX-2) plays an important role in the progression of at...
Delivery of lipophilic bioactives such as lutein and vitamin D into food products is challenging due...
Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne\u27s disease, a chronic progress...
In the last twenty years, interferon-α (IFN-α) has gained success as an immunotherapy for treating s...
Malignant pleural mesothelioma (MPM) is a highly aggressive tumour arising from the mesothelial cell...
Enumeration of bacteria has been the subject of research for over a century. Some of the techniques ...
Type 1 diabetes is the direct result of an autoimmune attack on the pancreatic islet cells. The isl...
The studies in this dissertation investigate neurodegenerative conditions of the central and periphe...
The expected growth of the older adult population in the United States over the next several decades...
Cyanobacteria are among the few microbes that have the ability to grow in elevated pH. The cyanobact...
CD4+ T cell responses are critical components of the immune response to viral infections, yet unlike...
Monoclonal antibodies are powerful and versatile tools that enable the study of proteins in diverse ...