The effect of cardiac rehabilitation on blood lipids was studied in a sample of seventeen male participants of the Greenville Hospital Center cardiac rehabilitation program. These subjects all suffered myocardial infarctions, but none had surgery to by-pass the obstructed coronary circulation. Paired values were obtained for triglyceride, serum cholesterol and HDL cholesterol before, and after the exercise program. The time span between the before-exercise and after-exercise values ranged from five to thirty-one weeks. The differences in the paired values were analyzed by the t-test. No significant decrease occurred in triglyceride or serum cholesterol. A significant increase occurred in HDL cholesterol