Add to ORKGThe role that in vitro systems can play in toxicological risk assessment is determined by the appropriateness of the chosen methods, with respect to the way in which in vitro data can be extrapolated to the in vivo situation. This report presents the results of a workshop aimed at better defining the use of in vitro-derived biomarkers of toxicity (BoT) and determining the place these data can have in human risk assessment. As a result, a conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process. The selection of BoT takes into account that they need to distinguish adverse and adaptive changes in cells. The framework defines the place of in vitro systems in the context of data ...
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragma...
In vitro chemical safety testing methods offer the potential for efficient and economical tools to p...
In chemical safety assessment, information on adverse effects after repeated dose and chronic exposu...
The role that in vitro systems can play in toxicological risk assessment is determined by the approp...
The role that in vitro systems can play in toxicological risk assessment is determined by the approp...
The role that in vitro systems can play in toxicological risk assessment is determined by the approp...
The current approach to human health risk assessment is an integrated approach requiring a significa...
Early consideration of the multiplicity of factors that govern the biological fate of foreign compou...
Chemical toxicity testing is moving steadily toward a human cell and organoid-based in vitro approac...
A special session at the Toxicology and Risk Assessment Conference in Cincinnati, OH, USA in May, 20...
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragma...
INTRODUCTION: Reliable in vitro and in silico assays as alternatives for in vivo developmental toxic...
There has been a dramatic increase in the development and use of in vitro systems in all types of bi...
Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Trad...
The introduction of in vitro methodologies in the toxicological risk assessment process requires a n...
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragma...
In vitro chemical safety testing methods offer the potential for efficient and economical tools to p...
In chemical safety assessment, information on adverse effects after repeated dose and chronic exposu...
The role that in vitro systems can play in toxicological risk assessment is determined by the approp...
The role that in vitro systems can play in toxicological risk assessment is determined by the approp...
The role that in vitro systems can play in toxicological risk assessment is determined by the approp...
The current approach to human health risk assessment is an integrated approach requiring a significa...
Early consideration of the multiplicity of factors that govern the biological fate of foreign compou...
Chemical toxicity testing is moving steadily toward a human cell and organoid-based in vitro approac...
A special session at the Toxicology and Risk Assessment Conference in Cincinnati, OH, USA in May, 20...
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragma...
INTRODUCTION: Reliable in vitro and in silico assays as alternatives for in vivo developmental toxic...
There has been a dramatic increase in the development and use of in vitro systems in all types of bi...
Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Trad...
The introduction of in vitro methodologies in the toxicological risk assessment process requires a n...
Based on existing data and previous work, a series of studies is proposed as a basis toward a pragma...
In vitro chemical safety testing methods offer the potential for efficient and economical tools to p...
In chemical safety assessment, information on adverse effects after repeated dose and chronic exposu...