Background: Microtubules (MTs) are protein nanotubes comprised of straight protofilaments (PFs), head to tail assemblies of alpha beta-tubulin heterodimers. Previously, it was shown that Tau, a microtubule-associated protein (MAP) localized to neuronal axons, regulates the average number of PFs in microtubules with increasing inner radius observed for increasing Tau/tubulin-dimer molar ratio Phi(Tau) at paclitaxel/tubulin-dimer molar ratio Lambda(ptxl) = 1/1. Methods: We report a synchrotron SAXS and TEM study of the phase behavior of microtubules as a function of varying concentrations of paclitaxel (1/32 <= Lambda(ptxl) <= 1/4) and Tau (human isoform 3RS, 0 <= Phi(3Rs) <= 1/2) at room temperature. Results: Tau and paclitaxel have oppos...
The molecular mechanism by which the microtubule-associated protein (MAP) tau regulates the formatio...
The microtubule cytoskeleton is essential for regulation of cell morphology, trafficking within the ...
SUMMARY Non-centrosomal microtubule bundles play important roles in cellular organization and functi...
Tau, a developmentally regulated protein localized to the axon of mature neurons, stabilizes axonal ...
Microtubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nanotubes wi...
AbstractMicrotubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nano...
Growing evidence continues to point toward the critical role of beta tubulin isotypes in regulating ...
In this review we describe recent studies directed at understanding the formation of novel nanoscale...
Microtubules (MTs) are essential components of the eukaryotic cytoskeleton. They form by the polymer...
International audienceDespite extensive studies, the molecular mechanisms of Tau binding to microtub...
Paclitaxel is a common chemotherapeutic that often causes peripheral sensory neuropathy. Paclitaxel ...
Microtubules are cytoskeletal polymers that are essential to many fundamental cellular processes, re...
Microtubules (MTs) are dynamic cytoskeletal polymers that are essential for many cellular processes,...
Microtubules are dynamic structures that are formed by the polymerization of alpha-beta tubulin hete...
As morphologically complex and polarized structures, neurons are critically dependent on cytoskeleta...
The molecular mechanism by which the microtubule-associated protein (MAP) tau regulates the formatio...
The microtubule cytoskeleton is essential for regulation of cell morphology, trafficking within the ...
SUMMARY Non-centrosomal microtubule bundles play important roles in cellular organization and functi...
Tau, a developmentally regulated protein localized to the axon of mature neurons, stabilizes axonal ...
Microtubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nanotubes wi...
AbstractMicrotubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nano...
Growing evidence continues to point toward the critical role of beta tubulin isotypes in regulating ...
In this review we describe recent studies directed at understanding the formation of novel nanoscale...
Microtubules (MTs) are essential components of the eukaryotic cytoskeleton. They form by the polymer...
International audienceDespite extensive studies, the molecular mechanisms of Tau binding to microtub...
Paclitaxel is a common chemotherapeutic that often causes peripheral sensory neuropathy. Paclitaxel ...
Microtubules are cytoskeletal polymers that are essential to many fundamental cellular processes, re...
Microtubules (MTs) are dynamic cytoskeletal polymers that are essential for many cellular processes,...
Microtubules are dynamic structures that are formed by the polymerization of alpha-beta tubulin hete...
As morphologically complex and polarized structures, neurons are critically dependent on cytoskeleta...
The molecular mechanism by which the microtubule-associated protein (MAP) tau regulates the formatio...
The microtubule cytoskeleton is essential for regulation of cell morphology, trafficking within the ...
SUMMARY Non-centrosomal microtubule bundles play important roles in cellular organization and functi...