Add to ORKGA large variety of peptides with different physical and chemical properties can be acquired by using different amino acids. Through chemical peptide synthesis, utilizing unnatural synthetic amino acids beside 21 natural amino acids, divergent peptides can also be obtained easily. Specifically amino acid and peptide conjugates of metals have received considerable attention due to their important role in many biological processes with unique structural properties. Moreover, it is well known that some metal ions are essential for living organisms and important for biochemical reactions as well as metal-amino acids and peptide complexes. The target of this project is to obtain metal binding artificial amino acids and to use these artificial ami...
Unnatural binding of peptides to metal centers were facilitated using covalent linkage methods. Fir...
Peptides and proteins can be either synthesized using solid-phase peptide synthesis (SPPS) or by app...
More than 50% of proteinogenic amino acid sidechains can bind metal ions, enabling proteins and pept...
Molecular recognition phenomena play important roles in a variety of physical, chemical, and biologi...
A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared...
The interest in peptide design with functional properties is a current thrust in research and their ...
The design, synthesis, and characterization of two novel metalloprotein motifs is presented. The fi...
Specific metal-chelating precursors incorporating a pendant protected (e.g. with Fmoc) amino acid fu...
Peptides are crucial ligands for transition metal ions and form complexes with them, that can have i...
Enzymes are Nature’s catalysts known for their high selectivity, turnoverrates, stereocontrol, low c...
An unnatural amino acid HPN, possessing a 2-pyridylmethylene group, which is a common fragment of se...
Metal ions are commonly seen in naturally occurring protein molecules, and often play pivotal roles ...
During the last years, the interest in combining the features of metal-containing molecules with bio...
Molecular recognition is the basis for most biological functions and in recent years the research on...
A novel strategy is presented for designing peptides with specific metal-ion chelation sites, based ...
Unnatural binding of peptides to metal centers were facilitated using covalent linkage methods. Fir...
Peptides and proteins can be either synthesized using solid-phase peptide synthesis (SPPS) or by app...
More than 50% of proteinogenic amino acid sidechains can bind metal ions, enabling proteins and pept...
Molecular recognition phenomena play important roles in a variety of physical, chemical, and biologi...
A novel non-natural amino acid designed to bind divalent metal ions, dubbed Lys(PYRIT), was prepared...
The interest in peptide design with functional properties is a current thrust in research and their ...
The design, synthesis, and characterization of two novel metalloprotein motifs is presented. The fi...
Specific metal-chelating precursors incorporating a pendant protected (e.g. with Fmoc) amino acid fu...
Peptides are crucial ligands for transition metal ions and form complexes with them, that can have i...
Enzymes are Nature’s catalysts known for their high selectivity, turnoverrates, stereocontrol, low c...
An unnatural amino acid HPN, possessing a 2-pyridylmethylene group, which is a common fragment of se...
Metal ions are commonly seen in naturally occurring protein molecules, and often play pivotal roles ...
During the last years, the interest in combining the features of metal-containing molecules with bio...
Molecular recognition is the basis for most biological functions and in recent years the research on...
A novel strategy is presented for designing peptides with specific metal-ion chelation sites, based ...
Unnatural binding of peptides to metal centers were facilitated using covalent linkage methods. Fir...
Peptides and proteins can be either synthesized using solid-phase peptide synthesis (SPPS) or by app...
More than 50% of proteinogenic amino acid sidechains can bind metal ions, enabling proteins and pept...