Surface modified multi-functional PCL/TCP fibrous scaffolds

Porous and fibrous scaffolds prepared using various methods are essential components of tissue engineering. Poly(ε-caprolactone) (PCL), due to its biocompatibility and mechanical properties, is one of the most desirable polymers in scaffold preparation for bone tissue engineering applications, and there are many studies on modification of PCL to enhance its biocompatibility. In this study, porous and fibrous scaffolds of PCL containing TCP were prepared by wet spinning and gelatin was immobilized onto it to enhance cell attachment on the surface. In order to increase the local antimicrobial agent delivery to the application site, gelatin microvesicles carrying a model antibiotic were adhered on the scaffold surface. Scaffolds were incubated with human osteosarcoma cells Saos-2 to study its biocompatibility and the antimicrobial effect on E. coli