Chromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 A

TP53 aberrations (deletions and/or mutations, TP53ab) in chronic lymphocytic leukemia (CLL) are associated with dismal clinical outcome and reduced life expectancy. However, mounting evidence suggests that within cases carrying TP53ab other cytogenetic features may also influence the clinical outcome. Alterations in chromosome 8, in particular 8p losses (affecting several regions, from 8p12 to 8p23) and 8q gains (usually involving 8q24, where MYC is located), are enriched in TP53ab patients and have been proposed as features with potential prognostic value within this aggressive group.Ye