Cryocrystallography of macromolecules features a high-resolution structure of individual atoms forming a nonsystematic lattice with internal dimensions interpreted by the diffraction of X-rays. By achieving the optimal conditions for crystal growth, a slow and controlled precipitation from the solvent creates a supersaturated environment to generate spontaneous nucleation of crystals. For this project, we are specifically targeting the protein structure of inhibitor vertebrate lysozyme (IVY) produced by Pseudomonas aeruginosa (PA). PA is an opportunistic pathogen that invades the host system during the latter stages of cystic fibrosis patients due to the weakened state of their immune system from earlier bacterial infections. PA is a virule...
X-ray diffraction from protein crystals remains the most reliable way to determine the molecular str...
The field of protein crystallography inspires and enthrals, whether it be for the beauty and symmetr...
The associated heavy (VH) and light (VL) chain variable domains (FV) of the monoclonal anti-lysozyme...
Cryocrystallography of macromolecules features a high-resolution structure of individual atoms formi...
Various biophysical methods were employed to structurally characterize and assess the activity of an...
Lysozymes play a key role in the innate immune system of vertebrates and invertebrates by hydrolyzin...
Lysozymes play a key role in the innate immune system of vertebrates and invertebrates by hydrolyzin...
Recent microbiological data have revealed that Gram-negative bacteria are able to protect themselves...
Pseudomonas aeruginosa (PA) is a Gram-negative bacterium, often found in cystic fibrosis (CF) patien...
The Lysinibacillus sphaericus proteins Tpp49Aa1 and Cry48Aa1 can together act as a toxin toward the ...
Protein crystals are generally fragile and sensitive to subtle changes such as pH, ionic strength, a...
Lysozymes are the first line of defense for a diverse range of organisms that catalyze the degradati...
Lytic transglycosylases degrade the murein polymer of the bacterial cell wall to 1,6-anhydromuropept...
Several Gram-negative bacteria protect themselves against the lytic action of host lysozymes by prod...
This is the final version of the following article : New crystallization strategies to fast-feed str...
X-ray diffraction from protein crystals remains the most reliable way to determine the molecular str...
The field of protein crystallography inspires and enthrals, whether it be for the beauty and symmetr...
The associated heavy (VH) and light (VL) chain variable domains (FV) of the monoclonal anti-lysozyme...
Cryocrystallography of macromolecules features a high-resolution structure of individual atoms formi...
Various biophysical methods were employed to structurally characterize and assess the activity of an...
Lysozymes play a key role in the innate immune system of vertebrates and invertebrates by hydrolyzin...
Lysozymes play a key role in the innate immune system of vertebrates and invertebrates by hydrolyzin...
Recent microbiological data have revealed that Gram-negative bacteria are able to protect themselves...
Pseudomonas aeruginosa (PA) is a Gram-negative bacterium, often found in cystic fibrosis (CF) patien...
The Lysinibacillus sphaericus proteins Tpp49Aa1 and Cry48Aa1 can together act as a toxin toward the ...
Protein crystals are generally fragile and sensitive to subtle changes such as pH, ionic strength, a...
Lysozymes are the first line of defense for a diverse range of organisms that catalyze the degradati...
Lytic transglycosylases degrade the murein polymer of the bacterial cell wall to 1,6-anhydromuropept...
Several Gram-negative bacteria protect themselves against the lytic action of host lysozymes by prod...
This is the final version of the following article : New crystallization strategies to fast-feed str...
X-ray diffraction from protein crystals remains the most reliable way to determine the molecular str...
The field of protein crystallography inspires and enthrals, whether it be for the beauty and symmetr...
The associated heavy (VH) and light (VL) chain variable domains (FV) of the monoclonal anti-lysozyme...