Synthesis and conformational analysis of cyclotetrapeptide mimetic β-turn templates and validation as 3D scaffolds
- Gentilucci L.
- Cardillo G.
- Tolomelll A.
- De Marco R.
- Garelli A.
- Spampinato S.
- Sparta A.
- Juaristi E.
DOIAbstract
The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetlcs 1-8 are essentially determined by the predisposition of the diamine to stabilize β-turns. The peptide mímete can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as avβ3-lntegrin receptor antagonists. © 2009 WJley-VCH Verlag GmbH & Co. KGaA
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