Insulin resistance, reduced b-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced b-cell mass and increased a-cell mass in the Type 2 diabetic pancreas. Confocal microscopy, real-time PCR and western blotting analyses revealed increased expression of PCNA and down-regulation of p27-Kip1 and altered expression of insulin receptors, insulin receptor substrate-2 and phosphorylated BAD. To investigate the mechanisms underlying these findings, we examined a mouse model of insulin resistance in b cells – which also exhibits reduced b-cell mass, the b...
AIMS/HYPOTHESIS: Insulin signalling pathways regulate pancreatic beta cell function. Conditional gen...
Dyslipidemia has long been associated with β cell dysfunction in the development of diabetes. Tang e...
Major bottlenecks in the expansion of human b-cell mass are limited proliferation, loss of b-cell ph...
Insulin resistance, reduced b-cell mass, and hyperglucagonemia are consistent features in type 2 dia...
Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 dia...
Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 dia...
AbstractDysfunction of the pancreatic β cell is an important defect in the pathogenesis of type 2 di...
Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood...
While several transcription factors are known to increase insulin production and secretion, their th...
Despite treatment with agents that enhance b-cell function and insulin action, reduction in b-cell m...
The expression of insulin receptor (IR) in β-cells suggests an autocrine role for insulin signalling...
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resi...
ObjectiveA major determinant of the progression from insulin resistance to the development of overt ...
<p>Aims/hypothesis: Insulin signalling pathways regulate pancreatic beta cell function. Condit...
Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. I...
AIMS/HYPOTHESIS: Insulin signalling pathways regulate pancreatic beta cell function. Conditional gen...
Dyslipidemia has long been associated with β cell dysfunction in the development of diabetes. Tang e...
Major bottlenecks in the expansion of human b-cell mass are limited proliferation, loss of b-cell ph...
Insulin resistance, reduced b-cell mass, and hyperglucagonemia are consistent features in type 2 dia...
Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 dia...
Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 dia...
AbstractDysfunction of the pancreatic β cell is an important defect in the pathogenesis of type 2 di...
Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood...
While several transcription factors are known to increase insulin production and secretion, their th...
Despite treatment with agents that enhance b-cell function and insulin action, reduction in b-cell m...
The expression of insulin receptor (IR) in β-cells suggests an autocrine role for insulin signalling...
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resi...
ObjectiveA major determinant of the progression from insulin resistance to the development of overt ...
<p>Aims/hypothesis: Insulin signalling pathways regulate pancreatic beta cell function. Condit...
Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. I...
AIMS/HYPOTHESIS: Insulin signalling pathways regulate pancreatic beta cell function. Conditional gen...
Dyslipidemia has long been associated with β cell dysfunction in the development of diabetes. Tang e...
Major bottlenecks in the expansion of human b-cell mass are limited proliferation, loss of b-cell ph...