Histopathological study of gall-bladder in north Indian population

Objective: To evaluate the histopathological pattern wall of human gallbladder in cholelithiasis.Methods: This was a cross-sectional study conducted in the Department of Pathology, May Institute of Medical Sciences, Barabanki, UP. Gallbladder of 50 cases aged 20-60 years were obtained from the General Surgery department of the institute.The sections obtained were carefully washed with 0.15 N saline. Then fixed into 10% formalin and processed for light microscopy. The sections were cut into 4 mm thickness and stained in H & E stain for evaluating the general histology. Different types of histological findings were noted in cholelithiasis gallbladder. The findings were noted in pre-design proforma. Results: About one fourth of the cases were between 21-30 & 31-40 years (28%). Majority of the cases were females (86%). Majority of the serosa was observed to be smooth (70%). Hyperplasia (28%) was found to be the most common microscopic findings followed by atrophied (18%). Normal mucosa was in 48% of the cases. Conclusion: Hyperplasia was found to be the most common microscopic findings followed by atrophied, ulcerated, intestinal metaplasia & proliferation with intestinal metaplasia as well as proliferation with intestinal metaplasia and ulceration with intestinal metaplasia