Prevalence of High and Low -level Mupirocin, resistance against MRSA from a tertiary care hospital in eastern UP

Aim: To determine the prevalence of High and Low -level Mupirocin, resistance against MRSA from a tertiary care hospital in eastern UP was the aim of this study. Methods and Material: A total of 62 non duplicate previously confirmed MRSA isolates were included in this study. The Susceptibility testing andresult interpretation for determining the high and low level of mupirocin resistance was performed by disk diffusion method using 200 µg and 5 µg disc respectively as per Clinical and Laboratory Standards Institute (CLSI) M100-S25 recommendations. Results: A total of 60 isolates (96.8 %) were found sensitive to mupirocin, 2 isolates (3.2 %) had low-level mupirocin resistance whereas none of the isolates was found to have high-level mupirocin resistance. Conclusion: The high-level mupirocin-resistant is uncommon in our patient population. The Periodic monitoring is useful for detecting changing trends in mupirocin resistance as a risk of emergence of high level mupirocin resistant strains is there