Add to ORKGHerein we report a thiol-labile cysteine protecting group based on an unsaturated pyridazinedione (PD) scaffold. We establish compatibility of the PD in conventional solid phase peptide synthesis (SPPS), showcasing this in the on-resin synthesis of biologically relevant oxytocin. Furthermore, we establish the applicability of the PD protecting group towards both microwave-assisted SPPS and native chemical ligation (NCL) in a model system
Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing a...
Peptide -thioesters are fundamental building blocks in peptide and protein science, providing powerf...
In the Fmoc-strategy of solid phase peptide synthesis, 1M trimethylsilyl bromide-thioanisole/trifluo...
Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide and prot...
Disulfide bonds are an important structural feature in many peptides. Controlled disulfide bond form...
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds...
International audienceThe development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioeth...
International audienceThe development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioeth...
International audienceThe development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioeth...
ABSTRACT: Contrary to other studies, here we describe cysteine (Cys) pseudoproline-containing peptid...
Thioamides are important biophysical probes of peptide folding but are prone to α-C epimerization du...
The Distributed Drug Discovery (D3) program develops simple, powerful, and reproducible procedures t...
Methodologies to conjugate proteins to property-enhancing entities are highly sought after. We repor...
Cysteine (Cys) is a key amino acid in many therapeutic peptides. For research and industrial purpose...
Oxytocin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc strategy. Benzyl ...
Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing a...
Peptide -thioesters are fundamental building blocks in peptide and protein science, providing powerf...
In the Fmoc-strategy of solid phase peptide synthesis, 1M trimethylsilyl bromide-thioanisole/trifluo...
Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide and prot...
Disulfide bonds are an important structural feature in many peptides. Controlled disulfide bond form...
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds...
International audienceThe development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioeth...
International audienceThe development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioeth...
International audienceThe development of phenyldithioethyloxycarbonyl (Phdec) and 2-pyridyldithioeth...
ABSTRACT: Contrary to other studies, here we describe cysteine (Cys) pseudoproline-containing peptid...
Thioamides are important biophysical probes of peptide folding but are prone to α-C epimerization du...
The Distributed Drug Discovery (D3) program develops simple, powerful, and reproducible procedures t...
Methodologies to conjugate proteins to property-enhancing entities are highly sought after. We repor...
Cysteine (Cys) is a key amino acid in many therapeutic peptides. For research and industrial purpose...
Oxytocin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc strategy. Benzyl ...
Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing a...
Peptide -thioesters are fundamental building blocks in peptide and protein science, providing powerf...
In the Fmoc-strategy of solid phase peptide synthesis, 1M trimethylsilyl bromide-thioanisole/trifluo...