Add to ORKGDrugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to offer insight into mechanism-based efficacy and adverse effects. Large databases of summary level genetic association data are increasingly available and can be leveraged to identify and validate variants that serve as proxies for drug target perturbation. As with all empirical research, Mendelian randomization has limitations including genetic confounding, its consideration of lifelong effects, and issues related to heterogeneity across different tissu...
Large-scale genome-wide association studies conducted over the last decade have uncovered numerous g...
BACKGROUND: Factorial Mendelian randomization is the use of genetic variants to answer questions abo...
Mendelian randomization (MR) is a technique that seeks to establish causation between an exposure an...
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be appro...
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be appro...
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be appro...
Evidence on the validity of drug targets from randomized trials is reliable but typically expensive ...
Insights into the genetic basis of human disease are helping to address some of the key challenges i...
Different statistical approaches have been implemented to overcome the limitations that typically an...
Common neurodegenerative diseases are thought to arise from a combination of environmental and genet...
Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental expo...
Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental expo...
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues...
Mendelian randomisation is an accessible and valuable epidemiological approach to provide insight in...
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues...
Large-scale genome-wide association studies conducted over the last decade have uncovered numerous g...
BACKGROUND: Factorial Mendelian randomization is the use of genetic variants to answer questions abo...
Mendelian randomization (MR) is a technique that seeks to establish causation between an exposure an...
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be appro...
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be appro...
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be appro...
Evidence on the validity of drug targets from randomized trials is reliable but typically expensive ...
Insights into the genetic basis of human disease are helping to address some of the key challenges i...
Different statistical approaches have been implemented to overcome the limitations that typically an...
Common neurodegenerative diseases are thought to arise from a combination of environmental and genet...
Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental expo...
Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental expo...
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues...
Mendelian randomisation is an accessible and valuable epidemiological approach to provide insight in...
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues...
Large-scale genome-wide association studies conducted over the last decade have uncovered numerous g...
BACKGROUND: Factorial Mendelian randomization is the use of genetic variants to answer questions abo...
Mendelian randomization (MR) is a technique that seeks to establish causation between an exposure an...