PurposeRepairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchymal stem cells (BM-MSCs) is beneficial to recovering haematopoiesis injury in radiotherapy; however, its mechanism is elusive. Our study aimed to help meet the needs of understanding the effects of radiotherapy on BM-MSC osteogenic potential.Methods and MaterialsBalb/c mice and the BM-MSCs were used to evaluate the irradiation-induced osteogenic differentiation injury in vivo. The cellular and molecular characterization were applied to determine the mechanism for recovery of irradiation-derived haematopoiesis injuries.ResultsWe report a functional role of IL-12 in acute irradiation hematopoietic injury recovery and intend to dissect the possibl...
Purpose: Whole-body radiation therapy can cause severe injury to the hematopoietic system, and there...
BackgroundDirect bone marrow injection of cells into murine marrow cavities is used in a range of ce...
Irradiation impacts on the viability and differentiation capacity of tissue-borne mesenchymal stem c...
PurposeRepairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchyma...
Total-body irradiation (TBI) followed by transfer of bone marrow cells from donors is routinely perf...
Many studies have already examined the hematopoietic recovery after irradiation but paid with very l...
Bone marrow mesenchymal stromal cells (MSCs) are precursors of adipocytes and osteoblasts and key re...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
Mesenchymal stromal cells (MSC) are progenitors of mesenchymal tissues including bones. Irradiation ...
Radiotherapy (RT) is a potent anti-tumor modality. However, unwanted effects including increased rec...
Adequate recovery of hematopoietic stem cell (HSC) niches after cytotoxic conditioning regimens is e...
Abstract Background IL-33 is a pleiotropic cytokine of the IL-1 family, which has been reported to i...
Background Radiation-induced injury after accidental or therapeutic total body exposure to ionizing ...
Radiotherapy puts bones at risk of developing osteonecrosis. Irradiation has an impact on the viabil...
It has been proposed that areas which border both bone and marrow contain specific niches which are ...
Purpose: Whole-body radiation therapy can cause severe injury to the hematopoietic system, and there...
BackgroundDirect bone marrow injection of cells into murine marrow cavities is used in a range of ce...
Irradiation impacts on the viability and differentiation capacity of tissue-borne mesenchymal stem c...
PurposeRepairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchyma...
Total-body irradiation (TBI) followed by transfer of bone marrow cells from donors is routinely perf...
Many studies have already examined the hematopoietic recovery after irradiation but paid with very l...
Bone marrow mesenchymal stromal cells (MSCs) are precursors of adipocytes and osteoblasts and key re...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
Mesenchymal stromal cells (MSC) are progenitors of mesenchymal tissues including bones. Irradiation ...
Radiotherapy (RT) is a potent anti-tumor modality. However, unwanted effects including increased rec...
Adequate recovery of hematopoietic stem cell (HSC) niches after cytotoxic conditioning regimens is e...
Abstract Background IL-33 is a pleiotropic cytokine of the IL-1 family, which has been reported to i...
Background Radiation-induced injury after accidental or therapeutic total body exposure to ionizing ...
Radiotherapy puts bones at risk of developing osteonecrosis. Irradiation has an impact on the viabil...
It has been proposed that areas which border both bone and marrow contain specific niches which are ...
Purpose: Whole-body radiation therapy can cause severe injury to the hematopoietic system, and there...
BackgroundDirect bone marrow injection of cells into murine marrow cavities is used in a range of ce...
Irradiation impacts on the viability and differentiation capacity of tissue-borne mesenchymal stem c...