Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
- Kira A. Perzel Mandell
- Nicholas J. Eagles
- Richard Wilton
- Amanda J. Price
- Stephen A. Semick
- Leonardo Collado-Torres
- William S. Ulrich
- Ran Tao
- Shizhong Han
- Alexander S. Szalay
- Thomas M. Hyde
- Joel E. Kleinman
- Daniel R. Weinberger
- Andrew E. Jaffe
Publication date
September 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The authors provide a comprehensive, single base resolution view of association between genetic variation and DNA methylation in human brain. They also show that heritability attributed to schizophrenia GWAS-associated variants reflects the epigenetic plasticity of the brain
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