Histone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological consequences such as neurodegeneration. Alzheimer’s disease is the most common neurodegenerative disease of the brain, which has devastating effects on patients and loved ones. The use of pan-HDAC inhibitors has shown great therapeutic promise in ameliorating neurodegenerative ailments. Recent evidence has emerged suggesting that certain deacetylases mediate neurotoxicity, whereas others provide neuroprotection. Therefore, the inhibition of certain isoforms to alleviate neurodegenerative ma...
Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervou...
Recent studies show that histone deacetylase 6 (HDAC6) has important roles in the human brain, espec...
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders...
By their ability to shatter quality of life for both patients and caregivers, neurodegenerative dise...
Neurodegenerative disorders (NDs) such as Huntington's disease, Alzheimer's disease, Parkinson disea...
AbstractModulation of gene expression is a constant and necessary event for mammalian brain function...
Modulation of gene expression is a constant and necessary event for mammalian brain function. An imp...
Epigenetic mechanisms have been recognized to be important for the physiologic regulation of cogniti...
Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of ne...
Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory a...
Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become established...
Advancing our understanding of neuroplasticity and the development of novel therapeutics based upon ...
Epigenetic gene control in the brain is a fundamental mechanism for orchestrating dynamic gene expre...
Histone acetylation is a prominent epigenetic modification of the central nervous system that is une...
Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with l...
Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervou...
Recent studies show that histone deacetylase 6 (HDAC6) has important roles in the human brain, espec...
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders...
By their ability to shatter quality of life for both patients and caregivers, neurodegenerative dise...
Neurodegenerative disorders (NDs) such as Huntington's disease, Alzheimer's disease, Parkinson disea...
AbstractModulation of gene expression is a constant and necessary event for mammalian brain function...
Modulation of gene expression is a constant and necessary event for mammalian brain function. An imp...
Epigenetic mechanisms have been recognized to be important for the physiologic regulation of cogniti...
Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal models of ne...
Histone deacetylase inhibitors (HDACis) have been shown to potentiate hippocampal-dependent memory a...
Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become established...
Advancing our understanding of neuroplasticity and the development of novel therapeutics based upon ...
Epigenetic gene control in the brain is a fundamental mechanism for orchestrating dynamic gene expre...
Histone acetylation is a prominent epigenetic modification of the central nervous system that is une...
Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with l...
Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervou...
Recent studies show that histone deacetylase 6 (HDAC6) has important roles in the human brain, espec...
Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders...